Genetics

Hi, please tell me for example how the overall risk of contracting a disease is calculated, knowing 60 SNPs related to that disease. For example the person has 60 SNPs related to schizophrenia with double risk allele. What is the overall risk for this person of contracting schizophrenia and how is it calculated? Thanks

There are genes that make proteins that make epigenetic changes to genes (for example genes related to H3K4 and H3K36 de/methylation and H4K16 de/acetylation, TrxG genes). therefore in the hypothesis that ageing is epigenetic rather than genetic it is still mostly genes that make proteins that make epigenetic changes to genes that are ultimately responsible for some of the epigenetic changes. therefore ageing would still be genetic in the epigenetic theory of aging; right?

Has any oncogene (cancer causing gene) been identified whose presence always causes cancer and whose absence keeps a tissue free of cancer? (I would have preferred to post this question in some medicine category, but was not able to find a suitable category, like oncology.) Jay

Hello, when I look at my genetics and there the GEN HLA-B in IGV - I would like to know how I can tell that I am HLA-B27 positive? The HLA-B gene has 7 exons and HLA-B27 should be between the 2nd and 3rd exon right? But what exactly makes HLA-B27 positive? BR Steffen

My Mum and Dad had me (obviously). My Mum's first cousin and my Dad's first cousin, married and had children: How are we related? We share two sets of great-grandparents. Thanks 😊

If I (white guy) were to move to South Africa and only have children with white women, would my descendants eventually turn black? If yes, How many generations would this take?

Hello, Gene for cataract is located on X chromosome. This disease is gonosomally recessive. Let's say two healthy parents have twins (both males - sons). I am supposed to decide whether those twins are monozygotic or dizygotic if: A) both sons have cataract; B) one son is healthy, the other one has cataract; C) both sons are healthy Also could you decide in this case about twins being monozygotic/dizygotic if they were females? Thank you for your help

I'm reading an article and I just stuck with it. I cannot get the difference. Tried to look around, got some idea but still not clear. Could somebody explain it to me in simple words or give me a link where it is explained, please? I couldn't find anything that could clarify it for me. Thank you.

Is it correct to claim that inversions cause more infertility than translocations and why would that be?

In this Topic, I will argue that research on race, brain size and IQ constitutes a significant line of evidence that supports a genetic model of racial differences in IQ. But before we turn to that topic directly, we need to differentiate phrenology research from brain size research. Phrenology was largely concerned with predicting people's psychological traits using the bumps and curves of their skulls. Empirically, this has been shown to be invalid (1). In contrast, meta-analyzes consistently show that brain size is positively correlated with IQ. In addition, a 0.19 correlation between brain volume and fluid intelligence was found in a pre-recorded analy…

In this topic, I will argue that human races exist, examine the most common arguments I hear in favor of racial denial, and explain why, in the final analysis, why they are wrong. first of all i want to leave a quote from my previous topic: Biological differences between races can be easily identified with any research method, be it RFLP or SNP. Either method identifies the same racial origin. A white is the white studied by SNP or RFLP. To say that there may be more differences between, of the same race than between, of different races (as deniers tend to lie) is totally false (and I will answer later why this statement is false). Genetic differences between…

Let's look at the liger. It does not have superior hunting capacities to the prides of the two different species (lion and tiger) it being larger no more makes it ferocious than another feline species, the Jaguar, at least not pound for pound the Jaguar is still more 'fit' The issue I have with hybridization is that at some point it dilutes the strain. And there is a real genetic basis for this, sure every once in a while you'll get liger-like advantages, but, eventually you have less variety/genetic components when one strain has more oil than water or more glue than rubber as it were. If you have a liger that is 99.999999999% Tiger and .00000000001% Lion than it wi…

How a normally pigmented child has albino parents? Does it mean that at least one of the parents is a chimera or is there another way? How often does it occur? (When we are given the sentence: All children with albino parents have albinism, do we take it as correct or should we consider the cases of chimerism?) Does it work the same way with PKU ? Thank you sooo much!

I have the FPKM values of around 7000 genes of an organism in a spreadsheet. I also have antiSMASH results for the possible bio synthetic gene clusters in the same organism. I am trying to figure out a way of classifying my individual genes from the spreadsheet to the predicted clusters. But haven't figured out. Does anyone have any clue on how I should proceed with it? Any hints would be helpful.

Dear all, I have been hearing abut how the body (gradually) replaces dead tissue, and replaces it with new tissue. Apparently, the whole body finishes replacing itself every 7 years! So this is my question. Do chromosomes replace themselves like the body cells do? (I think I already know the answer, but I want an in-depth explanation please:). Please get back to me on this. Yours sincerely, Salik Imran, 13.

Dear All I have the question to the expert about the alternative polyadenylation, is the last (distal) polyA in the gene always used in transcription termination and once pre-mRNA is formed the alternative polyA is chosen or is the transcription terminated once the particular proximal polyA is recognized? I will be grateful for your answer

I read that on January 10, 2020, after isolating the virus from patients, Chinese scientists posted its genetic sequence online . But it was not listed on NCBI until 18-JUL-2020. Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome https://www.ncbi.nlm.nih.gov/nuccore/1798174254 Why did it take so long to post in NCBI? Where did the Chinese originally post it? Also, is this the correct forum to post this kind of question?

I finished reading a Dan Brown book called Inferno, in which a madman decides to create and propagate a human created virus that targets human's reproductive system and renders them sterile through the water system in Istanbul. Is creating such a virus possible with modern day understanding of genetic engineering, and how effective would such a virus be? Assuming its spread to be as much as of the current pandemic, how much could the virus decrease the population increase rate?

In blood genotyping the letter I/i is used (IA, IB, i) to define the alleles. Why is the letter I/i used or where does it stand for? I couldn’t find anything on the internet...

At what point are human physical traits like facial features and body type set and impossible to change? Would, as an example, altering someone's DNA at age 10 to that of Neil deGrasse Tyson's cause his facial features to diverge significantly from how they would develop with his native DNA?

Hi Sorry in advanced for for my english. Recently im hearing scientific podcasts while jogging. One of them overwhelmed me with two claims that i just must vetify in order to sleep well. A genetics researcher claimed: 1. almost all creatures on earth that mutate with eggs can do it either by the preferred way with fertilizing the egg using the male, or cloning the mother without fertilizing if no male is around. For example an unfertilized chicken egg under special treatment (incubator?) can clone the mother chicken 2. mamal's male is transferring knowledge to its y genes with accordance to his life experience. For example, male mice were punished after sme…

Hi, all! I'm looking for information if the DNA in zygotes or in blastomeres of an organism are equal to DNA in somatic cells at later stages of the organism development. My understanding is that during the ontogenesis of organisms their DNA in specialized somatic cells are subject to more or less significant changes.However I could not find any info about it. I would appreciate any suggestions. Thanks!

My brother and I both have wide set eyes (eyes that are further than one eye width apart) and so does our dad. I've looked at celebrities who also have wide set eyes and it seems that more often than not, their children's eyes are also wide set. Some examples are Jaqueline Kennedy Onassis, Kate Moss, and Chance the Rapper. So my question is: are wide set eyes hereditary and/or are they a dominant gene?

Well, We researched and found a series of useful informations that make our minds opened the more! Knowledge of Races Vs Racism Firstly i forgot write the word 'Chinese' to the quoted scientific source from the most trusted scientists we have known. And the 5 races of generation of Japheth are Gog, Magog, Slavic, Turkish, Chinese. Secondly our discussion here is about connection between Genes and at all several useful informations for that that IF: There be any opposite saying/claim/source/experience, you introduce them to us then IF: One of them is truer than it, we zoom on that the more! And if there isn't any truer that t…

I asked this on Yahoo Answers and one person said that it is genetic. I am thinking since it is behaviour, intuition kind of makes me think, how does behaviour emerge from genetics? Seems like something they would learn from a their parents or something? Gorillas have been beating their chests since 50 years ago, is there some sort of culture involved in it all, why do all different groups of Gorillas know how to beat their chests? Have they kept the culture of beating their chests that well over 50 years (I know they were here longer than but just saying that to explain they been beating their chests consistently for years) Note: Silverback Gorilla is my favourite a…