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Dagl1 last won the day on January 7 2020

Dagl1 had the most liked content!

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About Dagl1

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    Maastricht, Netherlands
  • Interests
    Science; molecular biology (RNA and neuroscience (synaptic plasticity)), (quantum) physics, programming, behavioral psychology.
  • College Major/Degree
    2-MSc biomedical sciences (molecular biology) Maastricht University --- Tohoku University
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    Molecular biology, cell biology
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  1. A few questions and maybe some suggestions (that you need to verify and check, or use as step off points). I am not a statistician, but I do have experience with statistics. Hopefully I don't say anything just blatantly wrong;/ So you have k keywords, and their averages on a single day. Do you put k keywords into a single variable KEYWORD or do you want to measure whether there is a difference for every k keyword? If you want to do k comparisons, please apply some type of multiple comparison correction as your p value (assuming 0.05 is used as cut-off) only means the type of for a type 1
  2. Although you asked Markus, isn't there a lot of material on this? https://en.wikipedia.org/wiki/Heritability_of_autism Of course maybe you are just asking if there are other people in his family, regardless of how much it is inherited?
  3. I unfortunately am not of any help, but am curious to see how this advances and hope some people can hep you out! Well written account of what is up, although I do think you may need to elaborate more on what type of help you exactly want. The resources on various topics you ask for may be too broad (but you never know!). It would probably also help if you explain in more detail what you have done so far regarding the TensorFlow implementation and where you can't see a good way of doing it. Otherwise it may feel to some members that you are asking them to walk you through from start to finish
  4. Note: While writing this, and putting my thoughts on paper, I changed my mind, I am keeping my reasoning because the questions I want to ask still follow from them. Well I do personally hope that we may have a bunch of people there at that point 😛, because what if these aliens try really hard to use microexpressions or are mimicking the general human expressions in order to convey meaning. Anyway that is kind of off topic and more a joke than anything else. Thank you Markus for sharing this, whenever you explain things about how your brain and that of other people on the autistic sp
  5. I suppose 'plenty' is not a right word, but just so I do understand correctly (and understand the other people's responses as well): The sol system sun (our sun), contains radioactive isotopes, its not a first generation star, so supernovea have happened already. There is fission in stars, regardless if that contributes (or not) significantly to anything within the sun? When you say 'basically' no fission, do we mean: no fission, or fission happens but is basically irrelevant? I am asking because MigL says the following (so I assume that we just mean there is little fission compared to al
  6. You inherit them from your father and mother, maybe some combinations make very similar phenotypes, maybe just like with eye color, there can be some genes that are dominant or co-dominant. We inherit DNA (and maybe some epigenetic stuff), DNA leads to protein production, and all the proteins together will determine the phenotype (together with the environment). It is really difficult to predict emerging properties, especially when so many genes interact with each other. Thus by just inheriting the right combination, you may get phenotypes that are very similar.
  7. Ehh? He didn't say anything very controversial I think, so ye I think those other criticisms are valid? Like I don't think I have ever heard of anyone describing light as anything other than always being at c? The big bang thing seems pretty much how I have heard and seen it explained, the whole of space time expanding, no consuming anything. Am I missing anything? I was just interested in his statement about fission in stars?
  8. Oh, I thought there was. But maybe I am being a little pedantic, and you may mean there fission doesn't contribute to much in the star? It seems strange to me if there is no fission in stars , there are plenty of radioactive isotopes and it feels logical (I say feel because I don't know) to think that a place full of particles moving at high speed around and towards fissionable elements would also lead to fission?)
  9. Isn't this the same question? We don't know (or at least I don't) which parts of autism are reprogammable at age 10, we can only speculate about it. If the gut micriobiome can affect it THAT MUCH, then you could of course argue that even if you change the DNA of the whole head (or even the gut) you may not be changing the gut microbiome, therefore actually having less effect. But again, at this point is really speculative and I think the question is answered by (bold added by me for clarification)
  10. Pretty sure if you would that in an embryo, and you knew what to tweak then most likely. If you do it in an adult or a 10 year old, maybe, it depends on how much of those things are reversible, but maybe.
  11. Thank you! I would be careful with saying things like: The schizophrenia article is about a model for schizophrenia, which requires the loss of a single allele of SETD1A. The risk of getting schizophrenia increases from SETD1A mutations, but that doesn't mean that by fixing this mouse model we can also fix scihizophrenia, especially if someone has a SETD1A unrelated type of schizoprhenia? The paper regarding autism talks about how autism related symptons will be lessened in mice by correcting SHANK3, but also that SHANK3 is really rare (aprox 2% of autistic people have mutat
  12. They have? Links please, I am interested. I would say that memory formation potential and hormone related stuff will become different the most, other stuff almost by definition as well but I don't know how much of the initial neuron paths/connections will be able to change, that feels kind of structural. I don't think you will suddenly get Neil, but there will certainly be things that change in how it works in that person, and then many years later those differences and different behaviours will manifest more (I imagine that from the moment that you change this person's genes, him and wha
  13. Probably some bone structures will be set, but I suppose (ignoring the full on immune response this would probably elicit) skin colour and any other thing that is dependent on regenerating/remodelling tissue, will at least change a bit. Significant is more a measure of how sure we are, I think could definitely notice the difference, but how extreme those differences would be are hard to predict.
  14. Yes, it seems this is a possibility in black are my comments: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696326/ Communication between the systemic immune system and the brain and its consequence on microglia is a critical poorly understood component of the inflammatory response to systemic disease (78). Systemic infections activate neural and humoral pathways that communicate with the brain and initiate a coordinated set of metabolic and behavioral changes (79). However, these adaptive responses may become maladaptive when microglia have been “primed” by an ongoing pathology and re
  15. I don't know of evidence that there is a single gene or set of genes responsible for having 'wide eyes'. So whether 'wide eyes' are dominant, I don't know and don't think we know, but wide eyes are probably at least partially going to be hereditary, like most body features I think.
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