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Hans de Vries

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About Hans de Vries

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  1. Lets say you take some kind of cells that divide fast like white blood cells and change their epigenome to resemble some other kind of cells, muscle cells for example. What happens?
  2. Microbiome transplant reduced core symptoms of autism by almost 50%. FDA was so impressed that it fast tracked the treatment https://www.healio.com/pediatrics/autism-spectrum-disorders/news/online/{6b8a390d-1f6a-4f24-ac73-ee831f0c20e0}/fda-fast-tracks-microbiota-therapy-for-children-with-autism There are studies of mice developing schizophrenia like behaviors after a microbiome transplant from humans with schizophrenia https://www.biocodexmicrobiotainstitute.com/en/publications/schizophrenia-and-microbiota-has-link-been-confirmed Anxious mice become less anxious after a microbiome transplant from courageous mice and vice versa https://pubmed.ncbi.nlm.nih.gov/31124390/
  3. We all know the reports of microbiome transplant allevating symptoms of autism and even changing some personality traits. What would happen if you transplant a microbiome from another species (a tiger for example) into a human?
  4. What are your thoughts on hyperbaric oxygen therapy (HBOT) for brain disorders? Possible mechanisms of action; - reduction of neuroinflammation, oxidative stress and apoptosis - stimulation of angiogenesis, neurogenesis and synaptogenesis - repair of white matter - increase of blood volume and blood flow to the brain
  5. When you think will first drugs to repair damaged brain hit the market?
  6. Do they actually do MRI scans of peope admitted to psychaitric wards as a routine? Just askin'
  7. What kind of changes occur in the brain due to psychosis/schizophrenia? Is there actual loss of neurons and damage to white matter tracts? If yes, can similar permanent brain changes occur due to milder psychiatric diseases i.e. depression/anciety or bipolar?
  8. In the pipeline there are two drugs for autism that work on oxytocin. Maybe thay can work on psychopathy as well? Both have shown very promising effects (in phase 2 trials so far) for a condition once considered completely treatment-refractory.
  9. No. If it was a viable approach, it would have been approved already.
  10. Any potential pharmacological pathways? Two drugs for autism are currently in developmen, a condition previously considered untreatable.
  11. What are some potential pathways towards reversing structural deficits in the brain that are responsible for lack of empathy/inability to bond with other people, oresent in psychopathic individuals?
  12. Autistics have a strongly logical thinking process and a strong predisposition towards memorizing facts and putting them into categories. This is different from neurotypicals who have thinking process strongly driven by emotions and shaped largely by social consensus. Is it possible for a neurotypical to naturally possess the same thinking style without having other traits of autism (social awkwardness, repetitive behavior, sensory processing difficulties etc.)?
  13. Hi. How do we move past the stagnation of psychiatry? It is not moving forward very much. In treating depression/anxiety/OCD we are stuck with SSRI/SNRI since late 1980s and they are marginally more effective than tricyclic antidepressants which were discovered in 1950s almost by accidens. Newest drugs for schizophrenia are no more effective in treating it than drugs introduced in 1950s. For many things (negative and cognitive symptoms of schizophrenia, autism etc) we have no effective methods of treatment at all.
  14. In many psuchiatric/neurodevelopmental disorders extensive loss of grey matter and damage to white matter tracts is clearly present. In schizophrenia thinning of grey matter all across the brain is extensive, it can reach as much as 25% in some regions. What would be some potential strategies to restore lost grey matter? There is almost no neurogenesis in adult human brain outside a small part of hippocampus.
  15. Clinical trials as of now are very long and expensive, it takes $1-2 bln and 8-10 years for a promising molecule to be tested and approved. MAny promising drugs cannot be tested in trials because they cannot be patented. Are there any potential ways to shorten the process and make it less expensive?
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