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Jay Kulsh

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About Jay Kulsh

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  • Favorite Area of Science
    chemistry, biochemistry, evolution
  1. John, Thanks for pointing out similarity of GEIPE treatment to Cisplatin. GEIPE works by disabling the enzyme RnR which controls the bottleneck step in DNA replication. Cisplatin works in part by binding to DNA and inhibiting its replication. Advantages of GEIPE over Cisplatin: It is non-toxic, and therefore should have much wider applicability. (Cisplatin is primarily effective for testicular cancers.) It stops DNA replication -- only in cancerous tissues, as various experiments attest -- at more fundamental level by preventing synthesis of building blocks (4 bases) of DNA. Disadvantages of GEIPE over Cisplatin: It is non-patentable -- and thus of no interest to cancer institutions. This unique 'disadvantage' has won the day for more than 25 years. From the perspective of suffering and dying cancer patients, a way out must be found, somehow, some day.
  2. It is interesting that you wonder about the "model of the mechanism" for the effectiveness of gentle electrotherapy to treat cancer. My contribution to this therapy is just that. It is based on quenching of free-radical at the active site of enzyme Ribonucleotide Reductase (RnR) which is bottleneck enzyme for DNA synthesis as well as cancer growth. Here is my published article on the subject: https://cancer-treatment.net/novel-cancer-therapy-1997-article.htm More information is available at the home page of the website: https://www.cancer-treatment.net which belongs to a California Non-Profit. BTW, your link to the 1985 article is certainly better than mine. Thanks.
  3. Thanks for responding. I was a bit reluctant to provide link to the article since was not sure if I am in the right section of the forum. Here it is: https://cancer-treatment.net/Ref.7-Journal-Cancer-Research-Article-of-1985.htm What you are saying is true in general for cancer research, but not in this case. I spoke at length with the lead author of above study and he informed me that they could not get funding. Please see his letter to me: https://cancer-treatment.net/from-very-positive-cancer-therapy-study-author.htm This cancer treatment is certainly not toxic. And this treatment is just as effective in humans as in animals. Please see this scientific publication: https://cancer-treatment.net/languishing-promising-cancer-therapy-2014-article.htm
  4. I wish to discuss a Biochemistry-Biophysics based treatment of Cancer, that has been languishing for more than 25 years because it is not patentable. A 1985 study published in the journal Cancer Research showed 98% reduction of tumors in 5 hours over 5 days of treatment? Strangely there were no follow ups. Thanks. Jay
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