In various threads we have (albeit briefly) touched on the fact that resistant bacteria are starting to overwhelm our ability to treat them. Now the CDC has issued a new antibiotic resistance threat report, Basically every 4 hours a new resistant strain is detected and about 35k people die every year due to resistant strains. Countermeasures that have started since the last report came out (2013) were less effective than hoped. Among the biggest threats currently are resistant Acinetobacter, Candida auris, Clostridioides difficile (formerly Clostridium), carbapenem resistant Enterobacteriaceae, and resistant Neisseria gonorrhoeae.
There are a lot of issues that have to solved outside the clinical environment, such as reducing or stopping the massive use of antibiotics in agriculture. There, antibiotics are routinely used to fatten animals which results in massive amounts of antibiotics released into the environment and enter the human food chain. Another aspects are procedures in health care (including elderly care) which are often not up to par to limit microbe spread. The challenge is that a single failure can lead to spread through the health care services.
There are folks still hoping that we will find an alternative treatment that will be as useful as antibiotics (which we messed up badly) but so far not alternative golden bullet is really in sight (yes there are some developments which can be useful but for the most part they have potential and/or have not shown to be effective in vivo). As a result, it seems that we are indeed moving straight toward the projected post-antibiotic era.
Personally (and of course biased by my own research), I think we need to accelerate our understanding of bacterial physiology in order to develop effective countermeasures from the bottom up, as in most cases we only have a very rough understanding how antimicrobial substances actually kill bacteria (which to some extent is also true for antifungals and fungi).