Genetics

I have a polygenic score for baldness estimated based on the summary statistics from the UK Biobank. The polygenic score that I use is constructed purely for European descendants, and this score is highly predictive for one of the outcomes (income) in the UKBB male sample that I am interested in. However, when I replicate this analysis using the Health and Retirement Study, I found the opposite results (reverse sign), even it is not significant. My understanding is that I restrict people to non-Hispanic white males in HRS, and thus HRS should have the same results like that in the UKBB. Even though I understand that UKBB is much larger than the HRS sample and th…

Hello! I created a topic in the main section, but it was closed. I probably did not create it where I needed to. Create here. I'm interested in what is the simplest virus? So that its genome is as small as possible in size. Or, the simplest viroid? I want to try to create a virus at home. I don’t understand why you are losing my reputation. And what is evil in that I want to repeat everyday laboratory experience? They also react negatively to Russian forums. I thought at least there are people here .. Maybe it's because I don’t know English? Forgot to say, I use Google translator.

Trait 1, wing shape, two different alleles Dumpy and Scalloped; Trait 2, tarsi, two different alleles Truncated and Wild Type; Trait 3, two different alleles Vestigial and Wild Type; Note: These traits are imaginary and bear no relationship with the real ones in terms of inheritance pattern or chromosomal location. A first cross is set up with a Scalloped, Wild Type, Vestigial male and a Dumpy, Truncated, Wild Type female. On the F1 we obtain 132 male flies with the following phenotype: Dumpy, Truncated, Wild Type and 127 female flies with the following one: Dumpy, , Wild Type, Wild Type. A second cross is set up with a …

Can somebody help me with the following question: Is there a certain duration for gene knockdown using shRNA or is the knockdown permanent? Stay save and at home!

Hello there, I have this question that I can not surely answer. For me the Answer is no but I am not sure and I can not motivate. Can Someone help me trying to motive the answer? Thank you Kind regards

Which region should I target for floxing mice using CRISPR? Does somebody have a tip for choosing which region?

Immune system normally attacks virally infected cells because of that infected cells present mhc1. But also, virally infected cells are the self recognized cells. so it has also "don't eat me" signal on it. Although they have "don't eat me" signal how can immune system response to mhc1 and eat virally infected cells? So, if virally infected self recognized cells can be eaten by immune system, why aren't cancer cells not eaten. I know that cancer cells are self recognized also and they have don't eat me signals too. So, why immune system don't destroy them like virally infected cells? Can you advise me some articles about how immune system attacks self recognized cells? Th…

Hi, I'm an undergrad Philosophy student but have always had an interest in Biology. I take a deterministic stance and have wondered for years the general explanation behind every action / thought - why I choose X rather than Y. Kin theory appeared sufficient and fitting. Yet familiciade-suicide cases appear to undermine this. Can they be explained by kin theory? Apologies for my lack of specifity.

I was reading this Quanta article https://www.quantamagazine.org/how-nature-defies-math-in-keeping-ecosystems-stable-20180926/ And the following quote appears in it: “People have made a lot of progress in genetics by studying model organisms,” Can someone give me an example of progress being made in genetics by studying model organisms or explain in principle how progress is made by studying model organisms?

Dear fellow colleages I have come across the idea of splicing bioluminesent bactirium with the asian pear to create a super food. That eminates its own heat through the interation of oxygen and luciferin. Could we use this to create a crop that could survive a mild frost in lighter climates. Even go far enough to sustain growth in lower tempetures.

Hi, I am currently doing an assignment on genetic markers used in animal health but I am getting myself confused with some of the results found online. What is the difference between genetic markers and genetic testing? Help appreciated ASAP, Thanks!

Not sure if this is the correct topic area for this question and would like to be informed the appropriate location if I need to. I am writing a fiction story that includes a very key aspect involving cloning and would like assistance if possible on the correct testing methods to get from point A to point Z. Since this is a sci-fi fiction story I am not worried about legal regulations or cost, but more so the most accurate explanation. Subject zero is a dead corpse discovered of unknown origins (non-human), but has a humanoid appearance. The corpse has a high number of base pairs within its DNA, and the researches are working toward cloning this creature. Since …

Hi there! I come here because a doubt about Redundant Haplotypes and his repercussions. I have been doing my thesis for the grade of Biologist about the Evolutionary Significant Units, this are populations of organism that were genetically isolated and have a diferent genetic variability. To make a delimitation of ESUs we indentificate reciprocal monophyly on a genetic tree, in this case whit COI and some of this ESUs have redundant haplotypes with some other locations. ¿ This redundant haplotypes make this reciprocal monophyly no viable?¿ This redundant haplotypes indicate a genetic relation? I have this dudes because i read, that is very difficult t…

I am a layman who recently read Selfish Gene. In it RD says that we animals (including humans) like/love take care of their offspring because offspring have 50% of the their genes, since the purpose of life is to propagate your genes. I am proposing a thought experiment to challenge this. So, if parents love their children because children have 50% of their genes, what if we secretly switch babies at birth. Parents don't know that the baby was switched. But won't they love, take care of the baby anyway. So, the baby now will not have any genes of the parents but still parents will love the kid because they THINK that the kid is theirs. So, doesn't this show …

I really wish to have specifics on what attitudes and traits are heritable.

Is there any works of mendels related to F6 generation and its observations?

DNA and RNA ~ Genetic Material The compound between protein and nucleic acid is called protein nucleo. Nucleo proteins are constituents of chromosomes. Of the two compounds, only nucleic acids can carry genetic information from a parent to her offspring. So, actually nucleic acid is a genetic material or a factor of heredity, although chromosomes are commonly referred to as heredity factors. Nucleic acid as DNA material consists of DNA (deoxyribonucleic acid) and RNA (ribonucleid acid). To find out about DNA and RNA, let's look at the following description. 1. DNA (Deoxyribonucleic Acid) From various studies revealed that DNA is a carrier of most or all gen…

If I'm not mistaken the only time homologous pairs of chromosomes need to find each other is during gamete formation in preparation for crossover recombination. How do they find each other?

How would you archive a sample for later DNA whole genome sequencing? Also, which types of samples are ideal? I've read about hair and saliva, which is better? Is there a preservative that can be used? I've seen products like the Oregene kit for saliva. Is there a DIY version, or something for hair?

I wonder if there is a way I can insert a gene into the genome of a mouse embryo (using CRISPR for example) which then is only transcribed only if a certain pathway is active? Something like placing it at the same position as a gene in the pathway for example? (Excuse the layman terms, it's been a while since I studied these particular aspects of molecular bioloy).

I don't want to be childish. I ask because I wonder if it is purely a luck thing or there are other influences. I wonder what twins that grow up separately in other environments and families look like.

Hi, I treated the cells with 5-Aza-dc and TSA and analyze a specific gene transcription and found out that the gene was induced due to both treatment(q-PCR) relative to control. Then I preform a western blot and found out that the protein level was reduced. This kind of dis-correlation can happen with DNA methylation and histone actylation inhibitors? can someone give a reference for this kind of dis-correlation?

Hey asking likelihood of mistake from lab. I just completed a paternity test from a child I just found out about so no denial issues here but the child is my spitting image. I feel to pursue this matter beyond a paternity test makes me look crazy. What is chances lab made a mistake? Also chances of chimerism?

Hello! I know the rules from Mendel, but sometimes it’s not that easy. 1. Example: which hair Color the baby will have if: the Wife is brown-haired and her whole family is brown-haired too. Her Partners hair is Blond and the parents from him have blond hair. The woman is homozygous and dominant and the man is homozygous and recessive, right? I have read that the offspring of these two can only have the dark traits as phenotype and are a carrier of the blonde recessive gene (the offspring will be Heterozygotes and have 100% the dark traits from the mother but can pass the blonde recessive genes to their offspring then). Is this true? I mean I think that I have seen t…

Hello , I m confused by the plethora of information about Humane Genes online, Some say there is a difference between Non-Coding DNA and Junk DNA, some say there is NOT. I read it in rationalwiki Non-coding DNA" refers to portions of the genome that don't code for proteins, the Rest are Junk. As it says - what about Pseudogenes and JUNK RNA, are they Non-Coding or Junk ? Someone pls clarify these thing in layman term.