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Alfred001

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  1. TL DR: Is there anyone here knowledgeable about endocrinology, specifically hormone receptors, blocking them and upregulation? I'm wondering if you could tell me what is known about how receptor blockers cause regulation, specifically how long must you block a receptor in order to induce that response and how you might avoid that. THE LONG STORY: This relates to a potential anti-hair loss drug that runs into a problem related to this. The story is this: Clascoterone is being developed as a potential drug for treating male pattern baldness under the name Breezula (CB-03-01). Male pattern baldness progresses through DHT activating the androgen receptors (AR) in hair follicles, which over time makes the follicle go dormant. CB binds to androgen receptors so that DHT can't, preventing it from exerting its deleterious effect. Phase II trial data for CB shows that it is very effective up to the 6 month mark and then it stops working. People in the hairloss community have been speculating as to why that is and one hypothesis has been that, after 6 months of consistently blocking the ARs, AR upregulation is induced. Assuming it is so, is there some way to avoid that happening? If not for this problem, CB would be a great treatment for hairloss. Would cycling off the drug before AR upregulation is induced work? Say, taking it for 5 months then going off it and then back on? Basically, I'm hoping there's someone here knowledgeable about this who might have some ideas about how this might be avoided. Do you think there's an alternative explanation, other than AR upregulation?
  2. If I understand the argument correctly, it's that if you compare a set of all whole numbers to a set of all whole + half numbers, when you look at each set up to number 2, set 1 would be 1 and 2 (and 0?) and set 2 would be 1/2, 1, 1 1/2 and 2 - so set 2 has more numbers, but that's only if you look up to 2. If you look at the whole sets the size of each is infinite, so neither is bigger than the other. What am I missing here?
  3. All the typical weirdnesses of QM - the double slit experiment, observation collapsing the wave function etc. - are they still regarded as mysteries that need to be resolved, or is the view now that that's just how the universe is and there is no explanation beyond that?
  4. Have there been any great scientists since the 20th century who were religious? And I mean religious in the conventional sense of believing in some major religion, not religious in the kind of unorthodox way Einstein was.
  5. I think that was just one of the speculated hypotheses, I don't think the mechanism of action was known, but now Follica says microneedling induces the generation of new hair follicles through stem cell division. My concerns are the ones outlined in this video and I'm wondering if anyone is knowledgeable enough on this topic to tell me whether this is a realistic concern, given stem cell division in generation of new hair follicles
  6. I learned about it from a company called Follica which is developing a hair loss treatment. Here's an article summarizing the results they announced. I don't know whether there's independent research that found hair follicle neogenesis, but there is research showing microneedling induces hair growth in balding men.
  7. If you're unfamiliar with it, microneedling is a proceedure used for skin rejuvenation (including removing scars) and hair loss. A device is used to create many many tiny needle puncture wounds on the skin or the scalp. It's something htat is becoming increasingly popular, but it seems to me, with my limited knowledge, that there might be some cancer concerns here through two distinct mechanisms: 1) What is described here starting with the header "Dermarolling May Trigger Tumor Formation" 2) generation of new hair follicles through stem cells When used on the scalp, microneedling induces the creation of new hair follicles through stem cell division. From what I understand, cancer can happen when cells start dividing and don't stop when they are supposed to. The idea behind microneedling is to generate an immense number of stab wounds. For example, there are dermapens that stab with 35 needles simultaneously and people are supposed to move these around their head and cover the whole scalp multiple times, so the numbers are extraordinarily large. Seems to me with so much stem cell division, isn't there a risk of something going south? Is that a plausible scenario?
  8. #1 If you have a sphere with an axis through it around which it rotates, is the number of possible axis it can have finite or infinite? #2 This is maybe the same question in a different way, but what's got me confused is this: Is the number of possible positions (for a point) on a finite line finite or infinite? Because the way I'm thinking about it, you can take a point and put it a certain distance from one end of the line and then you half the distance and get another position and you half it again and again... you get the idea, you can half it an infinite number of times, which seems to give an infinite number of positions on a finite line. So how can there be an infinite number of positions on a finite line?
  9. I was reading this Quanta article https://www.quantamagazine.org/how-nature-defies-math-in-keeping-ecosystems-stable-20180926/ And the following quote appears in it: “People have made a lot of progress in genetics by studying model organisms,” Can someone give me an example of progress being made in genetics by studying model organisms or explain in principle how progress is made by studying model organisms?
  10. I will be using a 1.5mm dermaroller on my scalp as part of a hairloss treatment and I'm wondering: #1 What can I sterilize the needles with and how long do I need to soak them? #2 What should I use to disinfect the skin I will be needling?
  11. I'm not just looking at forums, but studies, including things that are in trials. Furthermore, even the stuff that is FDA approved works wonders for people and does squat for others, so it's not like the only possible scenario is you hit on a cure that works 100% for 100% of people and you're a billionaire. There are many different remedies that have small effects, many of them are natural and available for cheap in supermarkets so you can't make a killing off them. The studies I read and that got results aimed at killing bacteria. It's possible that their anti-bacterial also had anti-fungal effects, but fungi were never mentioned. You seem to be knowledgeable on this topic. Are you a dermatologist or have you studied this? ??? I've already mentioned two natural substances that have those properties
  12. There are only 3 FDA approved treatments for hair loss, so you know what the dr is gonna give you. There are big forums and communities around hair loss, as you can imagine, and people do a lot of research so they know what's out there and how effective it is. In most cases, if you want to have significant success fighting hair loss, you have to go beyond what the typical dr will give you and look into emerging treatments or stuff that's appeared in the literature more recently and is likely not known to your average dermatologist. No, the exact cause of male pattern baldness is not exactly known and it is believed that it might be multifactorial. Microorganisms and inflammation have been implicated and there's one study I read (albeit with a small sample size) where they were able to outperform one of the typical treatments (Minoxidil) by combining it with tea tree oil and an anti-inflammatory. The presumed mechanism was that TTO was killing whatever microbes were there and the anti-inflammatory was reducing the inflammation and that yielded results. Yep, Manuka is a good one and I've thought about it, but it's a little on the expensive side and possibly too expensive for what is, really, a speculative treatment that could go nowhere. Also, I should point out, I need something that has bactericidal, not just inhibitory effects. It needs to kill whatever is already there. But, I THINK, Manuka has that ability for a wide range of microbes. Yeah, a lot of essential oils are potent antibiotics, but, from what I've read, they're very dangerous and I'm a little afraid of using them. If anyone knows any safe one (I doubt such exsists) or can assuage my fears and knows for sure how they can be used safely topically on the scalp, you could help me out a lot. I'm open to this and maybe that would be the best option. It would have to be: - fairly cheap - come in some form that can be applied topically to the scalp (I'm not sure, but I believe that any substance applied to the scalp will find it's way to the blood through the hair follicles) - be free of any serious side effects If anyone can suggest something that meets those criteria, I'd be very grateful to you. Yeah, you're right about that, I just kind of assume that something natural is more likely to be something cheap and possibly have fewer side effect or toxicity concerns, but quite possibly none of that is true. So, just to update you all on where I stand with this, because my thinking has evolved since the original post. The point of this is that microbes and inflammation have been implicated as factors in hair loss and I'm looking for a way to fight them. I read a study where they achieved some good results through doing that, but I'm inclined to not use what they used in the study (tea tree oil and diclofenac), because of toxicity concerns and because I assume (haven't looked into it yet) that diclofenac is pricey. So, if anyone can recommend an anti-inflammatory and an anti-microbial that kills a broad spectrum of microbes (kills, not just inhibits), you could save me a lot of time, stress and aggravation. Both would have to be: - affordable - free of serious side effects - in a form that can be applied topically - safe for application to scalp (I'm not sure, but I believe anything applied to the scalp gets into the blood through the hair follicles) I looked into essential oils for anti-microbial, but got turned off them because of safety concerns. Lots of people ending up in comas and dead cats from essential oils. They can probably be used safely if properly diluted, but it would take a lot of research time (which I don't have) and I'm hesitant to take risks with them. If someone is knowledgable on this and can give me reliable instructions or point me to a resource where I might find them, I would still consider essential oils. Someone suggested hydrosols as an alternative and they seem to be perfectly safe, but I'm having trouble finding papers testifying to their bactericidal properties, only bafcteristatic (meaning, they inhibit). These are still an option as well, I need some evidence they can kill germs. So then I got onto honey, because it can both kill germs AND has anti-inflammatory properties. But honey has some problems which I won't get into, because this post is too long already. An alternative candidate I'm looking at now (tho honey is still in play) is olive oil, which, likewise, has both anti-microbial and anti-inflammatory properties and is, obviously, a food, so should be safe for topical application. If anyone knows anything on olive oil and can advise me on this, I'd appreciate it, because I wasted whole of yesterday on reading papers about the anti-microbial properties of various honeys and I'd very much like to not repeat that, as I have a life to get back to Beyond that, if you have any suggestions for an anti-bacterial and an anti-inflammatory, I'd love to hear them.
  13. I have a browser extension that makes background black and text bright to make things easier on the eyes, so I didn't even notice my post was in white font. Dunno why that happened. Can you think of any cheap, natural substance with broad antibiotic properties that I might use for this purpose? Something that can safely be applied topically to the scalp? I've been thinking about honey, but I can't tell from the papers I've been reading whether it merely INHIBITS colonization by bacteria or whether it actually KILLS bacteria that is there. When a paper says that honey INHIBITS bacteria, are they making a distinction there between inhibiting and killing or can I take "inhibits" to mean it kills bacteria? I can't edit the original post, so here's a repost in non-magical ink: Are there any essential oils that are known to be perfectly safe for topical (or oral) application by humans? I am looking for a topical anti-microbial to use in a hair loss regimen. Tea tree oil has been used effectively in a study I read, but I'm concerned about toxicity, so I'm looking for an alternative. I'm looking for something that could safely be applied to the scalp. Does anyone have any suggestions as to what I might look into as a possibility?
  14. Are there any essential oils that are known to be perfectly safe for topical (or oral) application by humans? I am looking for a topical anti-microbial to use in a hair loss regimen. Tea tree oil has been used effectively in a study I read, but I'm concerned about toxicity, so I'm looking for an alternative. I'm looking for something that could safely be applied to the scalp. Does anyone have any suggestions as to what I might look into as a possibility?
  15. I recently heard a girl talk about how she says she likes sweet, nice guys, but when she actually meets one, she finds that she finds them boring and that she is attracted to guys who treat her like trash. Is there some evo psych explanation to this and why girls like bad boys more generally and why nice guys are boring?
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