I used to think religion was the great filter, it was easy to think that religion would eventually kill us all but I've changed my mind. IMHO information will end up ending our civilization, information without conformation given in quantities so vast that conformation is impossible and the tendency to accept what we want to be true. At first information is a good thing but as it becomes a vast quantity of randomness coupled with the human tendency to try and make sense of the input you get outrageous conspiracies that need to make sense so we don't feel stupid.
The more outrageous the information the greater the need to make the info make sense. I was genuinely surprised number 45 didn't go for broke and say aliens were threatening us and he was the only one who could stop them.