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About Function

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  • Birthday 12/27/1996

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  • Interests
    Movies, music (where shall I start ...), neuro-oncology (with special interests in gliomas), neurology and neurophysiology (with special interests in epilepsy and (problems of) consciousness), endocrinology (with special interests in fertility, andrology, and endocrinology of the adrenal cortex)
  • College Major/Degree
    BSc in Medicine
  • Favorite Area of Science
    Medicine: neurology, neurophysiology, endocrinology
  • Occupation
    2nd year graduate student - Master of Medicine

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  1. First full version of my thesis complete! To be revised by my supervisors, and to be printed :wub::lol:

    1. studiot


      That must be a weight off your mind.


  2. is homosexuality unnatural and can be cured?

    Missed those allegedly self-conscious flippin' creatures. My bad.
  3. is homosexuality unnatural and can be cured?

    Please, give solid arguments why you think that. Above all, humans and higher primates are thought to be the only species to enjoy sex, and not only do it for reproductive purposes. So imho, this statement becomes false.
  4. Log transformation of negative angles

    Concerning type 1 errors: each patient had received a MR spectrum. Each spectrum had some characteristics (11, to be precise, of which 1 was categorical, the other ones continuous), which were all subjected to Shapiro-Wilk (in each subgroup per comparison), and variables with allegedly nonnormal value distributions were log-transformed, and the test was run again. And then, all variables were compared each time between 2 distinct groups (e.g., high-grade tumours v. low-grade tumours). I applied a Bonferroni correction in post hoc tests where more than 2 tumour categories were present (e.g., grade I v. grade II v. grade III v. grade IV), or when the categorical variable (which had 3 categories) turned out to be significantly different between any two (or more) groups. Post hoc chi-squared or Fisher's exact tests were then run, with Bonferroni correction applied to the significance level. For the other analyses, there was no need for type 1 error correction, as one could interpret each comparison to be a separate "study". Additionally, no variables were ever combined into one predictive model. That would have led me too far. I'll look for some articles that are representative for in vivo MR studies.
  5. Log transformation of negative angles

    There are differences in other parameters within comparisons of other groups, but for this one group–group comparison, only this variable differs significantly. I already implemented everything that’s usually used as parameters in MR spectro in human brains, but thought of ‘designing’ new parameters. Edit: after all, I aimed not only to confirm what is already known, but to develop some more unusual variables, as we are in search for optimisation of noninvasive diagnostic methods in tumour assessment
  6. Log transformation of negative angles

    I am looking at the entire spectrum, but certain frequency peaks represent very distinct metabolites. Change in protractor direction, would that actually not be exactly the same as adding 90 degs to every measured angle post hoc? And that’s the stupid part: a nonparametrical comparison of the original angles does not differ significantly between 2 groups, whereas the Briggs log of the angles + 90 degs does. And as my thesis actially focusses on tumour group classifications, I wouldn’t just consider this as a methodology designed “just to find something significant at one point”, but as a methodology to find and describe class predictors. First step in such process is assessing differences in parameter distributions between both groups ...
  7. Log transformation of negative angles

    Log and square root transformations are common transformations in statistics for variables that are nonnormally distributed, hoping to achieve normality in their log- or root-transformed variants. Which I got. IBM argues that it is possible to "add a constant big enough" to all values, such that no value is negative or zero, and then apply log transformation. An advantage to this method would be that simply adding a constant to each value does not alter variance amongst variable values. The situations you present are highly unlikely. We're talking about proton NMR spectroscopy of some in vivo metabolites. Achieving the situations you suggest are nearly impossible, as the peaks themselves will just stay where they are, and only chance in amplitude, not in frequency/chemical shift, which is displayed on the horizontal axis.
  8. Log transformation of negative angles

    Because that's how I defined my angle. It's always defined as the angle the line (or, if you like, vector) from the first to the second peak makes with a horizontal line. I wouldn't have liked working with (360° - (negative angle value)) to substitute the negative angles, as then I would have to conclude that the second situation would have a larger angle, which, according to the definition I gave to that angle, is absolutely not the case. The sign of the angle is inherently correlated with the characteristic of both peaks relative to one another (first peak higher, or second peak higher). The constant arrangement of both peaks on the horizontal axis made me define the angle to be indisputably either greater than -90°, or smaller than 90°. "Log transform a variable" is performing a natural Briggsian logarithm on all its values, and saving the results as values of a new variable.
  9. Hello everyone For my thesis, I'd like to log transform a variable that represents a certain angle between 2 peaks on a curve. The problem, of course, is that this angle can be negative. As no angle is smaller than -90°, would it be allowed to add 90° to all angles, and log transform the results into a new log-transformed variable? Thanks F
  10. Hello y'all In my thesis, I have this variable, which is expressed in a percentage (%). It's not an option to, e.g., display 20 % as 0.20, since that is absolutely not common for that variable. Now, this variable does not satisfy the conditions for parametric testing. However, its square-root variant does. But if I report both this variable, in %, then do I have to change the "unit" (which in itself is demensionless) to something else than %? Now I would report: Mean Var ± SD - % Mean VarROOT ± SD - % But I'm not sure if this is quite right. After all: e.g., in the case of 20 %, I took the root of 20, and not of 0.20. So ... sqrt(20 %) = sqrt(20) * sqrt(0.01) = 4.47 * 0.1 = 0.447 ~ 44.7 % And sqrt(0.20) = 0.447 ~ 44.7 % But erm ... Is there a symbol for 1/10? Because now I see that I would incorrectly report 4.47 % (since I only rooted 20 without the %) instead of 44.7 %. Thanks F
  11. So there's this gene, IDH1. It's responsible for the production of the protein IDH1.

    An c.395G>A mutation in IDH1 leads to p.R132H IDH1.

    So if a tumour is IDH1-mutated, can I say IDH1 is mutated? Or is "aberrant" more preferable?

    What do I call "p.R132H" if it is not a mutation?

    1. hypervalent_iodine


      I guess it depends on whether or not the mutation in gene sequence leads to a change in the amino acid sequence. In your example, yes, though I believe convention with proteins is to only capitalise the first letter, making it an R132H Idh1 mutant. I may be wrong in that though. Edit: just realised that the capitalisation is species dependant. I work with fungi, where you don't capitalise every letter, but I believe you do with humans. Go figure.  

  12. Let's say there's this Java-driven program (ran via a batch file), which requires (1) a licence file, and (2) a protected USB key that goes along with the licence file.

    Let's now say that there are 3 types of licence files: (a) a normal licence file that gives full access to the program, if the USB key is inserted in the computer; (b) a trial licence file that does not require the USB key in order to run the program correctly, but only gives access for 600 days; and (c) a licence file that was distributed in private for a course of the program, making it available only on the day of the course, without the need for the USB key (so with this licence file, the program will always run correctly and with full functionalities, if the system date is set to 13 May 2013, course day).

    Is there a possibility to adjust/create a licence file to eventually have one licence file that allows the program to be run with full functionalities, without need for USB key and system date settings?

    1. Show previous comments  1 more
    2. Function


      I've looked into runasdate, but it requires exe files, and doesn't work with batch files. (Found it impossible / too hard to convert the bat to exe, too).

    3. fiveworlds


      Okay then try this edit the .bat with notepad and add the following

      first line of bat or under @echo off

      date 13-05-2013

      last line of bat

      net stop W32Time

      net restart W32Time

      This will set the system time back to 13th May 2013 and run the program then reset your system time back to normal

    4. Function


      Ah yes, I've tried such deceptions, but there's one caveat: apparently the program rechecks everything every 5 minutes or so, so if the system date is reset while the program is already run, it will give a date error (licence outdated) and shut down.

  13. Hello everyone During the last sleepless night, some thoughts crossed my mind, and I wanted to share them with you and ask your opinion/points of view regarding them. The idea would be that the human brain maps, registers, and saves every single location a human being has ever been, and that, should we have the means to do so, a "route" could be mapped for every human being, from the moment they were born, until the moment they died. Useless, of course, but I wondered whether this could be the case. After all, our vestibular systems start working quite early; as do our memory circuits. Could it be possible that, from the moment your vestibular system was active, it would register any acceleration across and around any axis, the duration of the acceleration, and that your brain would register the duration of absence of acceleration, until further acceleration or deceleration occurs? For example: a child sits on a chair. It stands up (acceleration in both ventral and cranial directions), turns right (rotational acceleration) for 90°, starts walking (again an acceleration), turns 90° back to the left (rotational acceleration), and sits down on another chair (acceleration in dorsal and caudal directions). The idea here would be that the vestibular system detects any acceleration and deceleration (which are not mentioned here), the duration of an acceleration/deceleration, and that your brain could register the duration of absence of acceleration. Like so, it would theoretically become possible to reconstruct the path the child has done: ventrocranial acceleration and steady movement, stop, rotational acceleration and steady movement, stop, ventral acceleration and steady movement, stop, rotational acceleration (or deceleration when compared to the other rotation) and steady movement, stop, dorsocaudal acceleration (or ventrocranial deceleration) and steady movement, stop. I don't know if it's clear what I mean, but if this were indeed the case, to me this would sound like the positional path of every human could be retrieved and mapped, from the moment they were born, until the moment they died, since every position we've been in could be explained in function of all acceleration, decelerations, and steady movements we've done in our lives. This is nothing more than a thought experiment, of course, and yields not much practical consequences. But I was wondering whether you would think this would be plausible, or rather far-fetched and unlikely, due to limited storage capacities within our (spatial) memory ... I was also wondering whether this might contribute to so-called déjà vus. Indeed, one may experience a déjà vu based on what one sees or hears or whatever; but could a pure spatial déjà vu also be experienced purely by means of our vestibular system and memory? As if our brains would understand that, if we've been to B (from point A) before in our lives, and now we take a route to the same point B, but from another point (C), the combination of vestibular activity and duration of steady movements would lead us indeed to this point B? Regards F
  14. What is perpetual motion?

    Greetings! Do electrons and protons lose energy over time, as would a magnet lose its "magnetic strength/power" over (long) time? If not, then isn't their perpetual motion at variance with the laws regarding conservation of energy?
  15. I want to "upgrade" my waking-up experience. Ideally, I'd love to have an alarm clock which I can plug into my computer and transfer custom alarm sounds to (which don't give me a heart attack), and which has two speakers so I can put one at both lateral ends of my bed.

    My phone (iPhone 8) won't do it for two reasons: (1) I can't plug my speakers into this phone and make the alarm sound come from the speakers, (2) even if I got to accomplish this, every iPhone since the iPhone 7 has been infamous for not having a 3.5 mm headphone jack, which means that if I would use the lightning port to connect speakers to my phone, I couldn't charge it, unless I also buy an overexpensive wireless Qi charging thing.

    Does someone know if this even exists?

    1. koti


      You could buy an external bluetooth speaker and use your iphone as the custom sound alarm clock. Or you could use bluetooth to connect your phone to your PC. Both scenarios will let you charge your phone.

    2. Strange


      There is a smartphone app that (it claims) doesn't wake you up until you are in the right phase of sleep. The idea being that being woken at that point is less disturbing.

      Have no idea if it works or is completely bogus!