In last years, Elon Musk have been using Ozempic against obesity:

https://www.axios.com/2024/12/26/elon-musk-ozempic-mounjaro-weight-loss

As far as I can see, the Ozempic can be considered as a psycho-active drug (usually, the pleasure from eating is maybe rather psychological then physiological).

And here is some more information: it seems that last time Musk have lost his mind:

Maybe these two facts are related?

40 minutes ago, Linkey said:

As far as I can see, the Ozempic can be considered as a psycho-active drug

Probably better / smarter to focus instead on his extensive use of ketamine, adderall, and related other psychoactive agents. IMO, ozempic is the least impactful least relevant item impacting his brain function. .

EDIT: I see this is a dupe of an already trashed thread anyway: https://scienceforums.net/topic/136020-elon-musk-and-ozempic/

Should be more worried that using Semaglutide, the active ingredient in Ozempic, doubles the risk of non-arteritic anterior ischemic optic neuropathy.
NAION is a condition that deprives the optic nerve ( and related retinal receptors ) of blood flow, causing cellular death and non-reversible vision loss.
This is somewhat related to the effects of Glaucoma ( and the reason for my interest ).

Don't yet know if the studies that suggest this result were influenced by the test subjects having the pre-existing diabetic condition, which usually causes problems with capillary blood flow.
Lose weight the old-fashioned way; reduce caloric intake of eating/drinking to a level below the caloric output of your activity/exercise.

Edited June 10Jun 10 by MigL

3 hours ago, Linkey said:

https://www.axios.com/2024/12/26/elon-musk-ozempic-mounjaro-weight-loss

As far as I can see, the Ozempic can be considered as a psycho-active drug (usually, the pleasure from eating is maybe rather psychological then physiological).

I don't see how this link supports your assertion that Mounjaro is behind Musk's recent bizarre behavior. There's no psych-activity in that article from Axios.

4 minutes ago, Phi for All said:

I don't see how this link supports your assertion that Mounjaro is behind Musk's recent bizarre behavior. There's no psych-activity in that article from Axios.

The idea of psycho-activity is mine: previously I watched a science blogger who said that our pleasure from food is psychological to a significant extent. So I thought that suppressing this pleasure is a psycho-activity.

Source: Extraction from rectum. See also: Trust me, bruh

5 minutes ago, Linkey said:

The idea of psycho-activity is mine: previously I watched a science blogger who said that our pleasure from food is psychological to a significant extent. So I thought that suppressing this pleasure is a psycho-activity.

Yeah that is wide stretch. Any kind of enjoyment by definition provides pleasure in psychological sense. That way, you could classify books as psychoactive drugs for book lovers.

3 hours ago, Linkey said:

As far as I can see, the Ozempic can be considered as a psycho-active drug (usually, the pleasure from eating is maybe rather psychological then physiological).

You need to substantiate this, too.

GLP-1 drugs slow digestion and make you feel full despite eating less. I never noticed any effect on my enjoyment of food. Just being satisfied with smaller portions.

https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists

At best one could say that semaglutide and related formulae, insofar as they affect areas of your brain that process hunger and satiety, have a neurological effect. Which is not the same as psychoactive. Acetaminophen affects areas of the brain and nervous system but we don't consider it psychoactive. While it might mean my shoulders ache less after pruning the hedges, it is not meeting the definition of directly causing changes in mood, awareness, thoughts, or feelings. Coffee OTOH is psychoactive. Pretty much everyone not a devout Mormon or extremely isolated hunter-gatherer tribe member can describe the mental changes from caffeine.

Excellent point

44 minutes ago, TheVat said:

Pretty much everyone not a devout Mormon or extremely isolated hunter-gatherer tribe member can describe the mental changes from caffeine.

No! Leave my caffeine alone!

... sorry, what were we talking about again?

12 hours ago, swansont said:

You need to substantiate this, too.

I tried to find studies relating the connection between the pleasure from food and phychological factors; GPT agreed with this statements, and provided me a lot of refs like these:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3498255/#:~:text=In%20the%20present%20studies%2C,about%20orange%20juice%20%28suggesting

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/166275/arcp1069.pdf?sequence=2#:~:text=We%20also%20identify%20key,marketing%20context%2C%20including%20social

https://journals.sagepub.com/doi/10.1177/2158244021989318

It is not clearly stated in these studies what I wrote, but the number of refs also matters, and in general, the refs lead to this conclusion.

14 hours ago, CharonY said:

Yeah that is wide stretch. Any kind of enjoyment by definition provides pleasure in psychological sense. That way, you could classify books as psychoactive drugs for book lovers.

…and from the rectum too, acc. @iNow . Sounds uncomfortable…..

1 hour ago, Linkey said:

I tried to find studies relating the connection between the pleasure from food and phychological factors; GPT agreed with this statements, and provided me a lot of refs like these:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3498255/#:~:text=In%20the%20present%20studies%2C,about%20orange%20juice%20%28suggesting

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/166275/arcp1069.pdf?sequence=2#:~:text=We%20also%20identify%20key,marketing%20context%2C%20including%20social

https://journals.sagepub.com/doi/10.1177/2158244021989318

It is not clearly stated in these studies what I wrote, but the number of refs also matters, and in general, the refs lead to this conclusion.

None of these links provides any support for your idea that these weight loss drugs can explain bizarre behaviour.

4 hours ago, Linkey said:

I tried to find studies relating the connection between the pleasure from food and phychological factors;

Nobody has denied this connection. You claimed that Ozempic and Mounjaro affected these, and you have given no evidence of that.

Nobody has denied this connection. You claimed that Ozempic and Mounjaro affected these, and you have given no evidence of that.

I watched this information somewhere in a vlog. Currently I tried to find this information, and found e.g. the following:

https://www.scientificamerican.com/article/why-ozempic-and-wegovy-might-change-your-favorite-food

GLP-1 drugs—initially designed to help treat type 2 diabetes by triggering insulin release—can cause weight loss by making people feel full faster. But some people report that in addition to an increase in satiety, they experience changes in their preferences for specific foods—they find meats suddenly repulsive, fried foods too heavy and savory snacks unappealing. On online forums and in scientific surveys, some people have expressed a general loss of interest in food overall—a few have even said that the drugs have redefined food as a necessity rather than a joy for them.

4 hours ago, Linkey said:

Nobody has denied this connection. You claimed that Ozempic and Mounjaro affected these, and you have given no evidence of that.

I watched this information somewhere in a vlog. Currently I tried to find this information, and found e.g. the following:

https://www.scientificamerican.com/article/why-ozempic-and-wegovy-might-change-your-favorite-food

GLP-1 drugs—initially designed to help treat type 2 diabetes by triggering insulin release—can cause weight loss by making people feel full faster. But some people report that in addition to an increase in satiety, they experience changes in their preferences for specific foods—they find meats suddenly repulsive, fried foods too heavy and savory snacks unappealing. On online forums and in scientific surveys, some people have expressed a general loss of interest in food overall—a few have even said that the drugs have redefined food as a necessity rather than a joy for them.

“Some preliminary evidence suggests changes in food preferences might play a role in weight loss, but it’s not clear how much such changes contribute to that result compared with the medications’ effect on satiety.

…

These findings rely on self-reported data, however, which can sometimes be unreliable“

Sounds like a side-effect, not the mechanism.

And you haven’t established this is true for Musk.

elon is sometimes crazy af....