Organic Chemistry

Hi, I've been performing a series of reductive aminations using refluxing toluene & toluenesulfonic acid and a Dean-Stark apparatus then reducing with NaBH4. So far it's worked with every example BUT this one has gone awry 3 times: I'm guessing that the pi-bonds of the benzene and the enamine are reducing the stability of the -F (it only loses an o-F). Would the use of a dehydrating agent like TICl4 prevent this? I only ask because I have to have the series ready so I'm going on with others while I ponder (and shout a plaintive help). Any help would be gratefully received. Thanks.

Hi, In the context of the synthesis of a coordination compound were added 1 mmol of copper (I) bromide with 1 mmol of 2,5-dimethylpyrazine and were stirred in acetonitrile. Here, a solid precipitated from X, which was filtered off and dried. An elemental analysis gave the following values​​: C: 28.65%, N: 11.12%, H: 3.21%. The content of Copper and bromine additionally by atomic absorption spectroscopy (AAS) was determined: (Cu: 25.25%, Br: 31.75%). As ratio formula I've got CuBrC6H8N2. But what's the molecul formula??? Can somebody help me??

VŒš Microsoft Word •¶žƒ.dochello, today I went over a ppt about organometallic compounds and I found I can't figure out why this equation could happen, can someone help me ?

I was reading about a drug called "Sufentanil" today. Apparently this substance is 500-1,000 times more potent than morphine. Why would anybody need to use this? Wouldn't this kill a human being? Basic Info - Generic Name: Sufentanil Brand Name: Sufenta Formula: C22H30N2O2S Structure:

just the simple question--how would i determine which group would exert which type of electronic displacement effect on the+organic compound and ,moreover how will i determine whose effect would be dominant over others(suppose two grps have +i and -i on the ring or like chlorine which has +m as well as -i,so how would i determine which would be dominant).

Hi, I am curious as to weather or not a chemical can attract another chemical through very thin atomic structures. Thanks

Could someone tell me what is the incomplete combustion formula for heptane?

Nevermind...I can't upload a picture or a model like I thought I could.

Hello everyone, I'm sure everyone has heard the statement that when distilling moonshine, the first few ounces should be discarded due to the concentration of methanol. Most sources of this statement make the claim that because Methanol has a lower boiling point than ethanol, the methanol will boil off first and will be the first type of alcohol to work it's way through the still. A friend of mine told me that this wasn't true, and that regardless of the difference in boiling points, a simple still would not be able to effectively separate the two. He said it mostly has to due with the low volume of Methanol that exists to begin with. He referenced Raoult's Law an…

How many mole of (NH4)2SO4 to add to 1 mole of NAOH for ammonia gas production. What is the correct ratio.

I bought some M.E.K. substitute from home depot since I read on the MSDS that it was 100% Ethyl Acetate. So I did an evaporation test on some glass and it left a film so I decided to distill it just in case. Anyway the ethyl acetate was clear when I started now its slightly yellowish and still leaves a film. What makes it yellow and should it concern me? Also is the film normal? Thanks.

I'm trying to do a reaction between an alkyl iodide (a little bit unstable) and piperazine, in order to obtain the monoalkylated piperazine. However, I'm having trouble obtaining a good yield and controlling the mono/dialkylation ratio. Could anyone help with suggestions?I've tried to do the reaction with 2 eq. of piperazine monohydrochloride in EtOH, and a yellow solid was formed. However, the product seems to stay in the aqueous phase during the work-up... How can I obtain it from the aqueous solution without extract the piperazine?

Can anybody help me with synthesis of 2,3-dihydroindole from 2-nitrotoluene. I need make it up in about seven steps. Thanks

Was looking at tutorials to show to my class this next week and came across this pretty entertaining, creative, and informative video. Everybody should definitely check this out!

1- 1) Iron metal is magnetic. 2) Copper conducts electricity. 3) The mass of the NaCl sample is 30 grams. 4) Gold is nonflammable 5)Diamond is a very hard substance. I should identify the following properties physical or chemical but I could not decide 2- - Formation of snow - cooking - condensation of rain - nuclear fission - photosynthesis which ones are exothermic reactions and do their temperature rises/falls?

Sulphuric acid is very important chemical compound and used in mostly al the indutries. it is used in the manufacturing of fertilizers just like supper phosphate and ammonium nitrate, as well as rayon and plastics. It is also used in the production of HCl and HF and in pickling of steel. It is also used in the preparation of detergents. It is the one of the best dehydrating, nitrating and drying agent. That is way it is called king of compond.

Dear all, I am trying to make this compond ( attached) and I am not getting anywhere. I have done the reaction by Dropwise addition of boc-protected hydrazine to 1,3-diiodopropane at RT using ACN as solvent and a catalytic base ( NaHCO3). Can you recommend any other reaction media? Suggestions? Reaction.pdf

Hello, I'm writing up some work on opioids and am trying to decide how to name them. Having spent a while slogging my way through the IUPAC rules I've come up with a few different ways, all are semisystematic in that they incorporate either the parent 'morphinan' or 'oripavine'. I'd really like some feedback, comments, objections, suggestions, etc. from other chemists as to what they think. All comments very welcome; you don't need to go through checking all of the stereochem (though please do if you'd like!). Examiner quite big on conformity to conventions, which is no bad thing necessarily, so closer to the IUPAC perfection, the better! As my compounds are s…

Hey, I just came across this technology that involves a biotin-based biological binding method with increased enzyme resistance for in vivo targeting and more. I thought this was pretty awesome because it can provide non-radioactive targeting (for specific compounds). Does anyone know if that would be possible with this technique? Or maybe it's better suited to something else? You can see the details here: http://marblar.com/challenge/biotin

I made sodium acetate by mixing distilled white vinegar with baking soda, with a little excess vinegar so that all of the baking soda reacted. Then I heated it on the stove until all of the water evaporated. This formed anhydrous sodium acetate. Upon farther heating, this turned completely into a black liquid that smelled TERRIBLE. Sodium acetate decomposes before melting (according to Wikipedia) into acetone and sodium carbonate. Acetone would definitely explain the reeking smell, but what is the liquid? Sodium carbonate remains solid sodium carbonate up to 851C, which I know I didn't reach on my stove. Acetone boils at well under the decomposition of sodium acetate, so …

This is what my born again Christian friend tries to explain to me everytime we talk about evolution. In the past I've held my ground quite firmly on this topic, but as of recently he has made some claims from some "scientific journals" that carbon dating may not be as accurate as thought, and that it is misleading. I have a hard time believing anything he really says about this, but my question comes down to this, how accurate is carbon dating and how sure are we it works?

Hi all, I need to produce some of this rather unpleasant smelling gas for a bioassay. Can anybody please suggest an easy (pseudo-home) chemical reaction with ideally, easily obtainable/not-too-expensive compounds that will form this gas upon reaction? Although Sigma do sell the gas (neat), as I only need a limited/small quantity for my tests, I do not want to order cylinders of the stuff, which incidentally are not only currently out-of-stock are also also very expensive. My limited Chemistry back ground has revealed the following: "Sodium merthiolate sold on the market is spontaneously converted to methanethiol in acidic medium". In addition, Wikipedia sug…

Hello I did some Googling but can't seem to be able to figure this out. The difference between iso pentane and neo pentane is in the molecular structure, they both have 5 carbon atoms. 1. why is endorphin so different from neo endorphin? endorphin has nearly 3x the number of carbon atoms as neo-endorphin 2. what's the practical function of neo-endorphin and endorphin? which is the 'happy' chemical? 3. in terms of practical purpose, which is more important, alpha or beta endorphin? Thanks

hi friends Q : has any one heard of reducing only one ketone when two are neighbored next to each other ? i want to know if it's possible and whether it has been done before or not. if anyone knows something about it (patents or anything) I'd be thankful to hear about. in fact i want to guess the mechanism for it. I'm asking because it happened in my reaction pot in a yield of around 55%. maybe it's some new stuff. I don't know. I hope it is. picture is what I've done :

Hi, I make a pyridine salt which contains the pyridine and an organic weak acid. The standard procedure to isolate the acid and remove the pyridine is to dissolve the salt in Diethyl ether with HCL, and let the diethy ether evaporate, which leaves the organic acid crystals with purity 99%. But i would like to use something else, less flammable than ether to isolate the said acid. Do you have any idea what could be used? The acid is composed of C H O and is completely insolube in water. It is mildy soluble in alcohols and quite soluble in dichloromethane. Thanks for any motivated suggestion. Regards