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Everything posted by Arete

  1. Good luck fitting a toolbox in the tray though. I can see it as a mall crawler/toy hauler, but having just tied down an ls3 in the bed of my Frontier today and hauled straw on the weekend, I can see a lot of things that would have been troublesome with the design of this truck for actual truck use. I applaud them for the ingenuity, but I think it got int he way of practicality.
  2. Arete

    Impeachment Hearings

    I'm not a US citizen but it seemed like the last election went a bit like this: "USA, this election you have to drink piss. We have this stale, slightly rancid cup of piss, very similar to the piss we've served for decades. It's not particularly palatable to many of you, but we know what we're getting and if you hold your nose as you sip, you'll be fine for the next four years. Or we have this big gulp of steaming walrus piss. It smells awful and it might give you syphilis, but honestly, we're really not sure what it's going to do." "Give us the Walrus big gulp. We're sick of being fed the same old piss. Drain the Walrus! Lock up the cup!" "OK..." Now we're three years into the Walrus piss big gulp. It's been a ride. Some of us are tripping balls and think the walrus piss is better than champagne, even though we might actually have mouth chlamydia and explosive diarrhea. Some of us hated it from day one. Many of us are not yet ready to go back to the same old, lobbyist corrupted, stale piss we had before, and want to swig more Walrus piss just to see where we end up. So now we're doing an MIC test on the Walrus piss to see if should even be an option.
  3. I think it requires a rather profound misunderstanding of how science funding works to make that argument. To explain for those following - say I apply for a federal grant. The whole packet might be 50-100 pages of densely written technical documents. I will probably take me a month or more to put together. It has a 10-20% chance of being funded, and if it's a big one, might net $1 million dollars of funding. My institution immediately takes 55% as overhead. The vast majority of the rest will pay for the salaries of the people I employ. Some will go towards lab costs. If I'm lucky I might get to claim one month of summer salary (for the three months of the year the university doesn't pay me) for 3-5 years. Ergo, I might actually pocket a few thousand dollars at best. On the other side, Ian Plimer - a mining geologist who doesn't even work on climate science, pockets over $400,000 per year from the fossil fuel industry, and "coincidentally" is an ardent critic of climate change. If I'm going to make up data or espouse a false belief for profit, I'm sure as hell not going to be saying climate change is real.
  4. One of the representations that has always bothered me, being a scientist, is that a "scientific consensus" is a bunch of us sitting around in tweed jackets, smoking pipes, sipping scotch and all nodding in agreement with one another. A scientific consensus occurs when a bunch of different data all converge on the same conclusion. Provided it's collected using best practices, data can't be political in of itself, it just, is
  5. It's certainly not that clear cut. Conservation Science is a significant field of scientific study, with journals, societies, funding agencies. There are multiple scientific journals that publish studies specifically on the mitigation of climate change. There is an entire bureaucratic structure in most developed countries to provide scientific input to governmental policy decisions. Applied fields of science certainly do cross over with policy, and the line between science and policy/conservation/government is necessarily blurry.
  6. Yes - you're right. In my lab we've been experimenting with disabling known resistance genes by inserting frameshift mutations to revert resistant strains back to susceptible phenotypes, but that is distinct from generating susceptible strains of inherently resistant wild type strains.
  7. Artificial selection is not necessarily quicker than evolution, but using CRISPR Cas9 approaches, it is simple enough to produce antibiotic susceptible strains. Aseptic technique is still the most valuable tool in the prevention of nosocomical infection. Spreading pathogenic bacteria about an OR - drug susceptible or not, would have significant detrimental effects. So a few things 1) Often antibiotic resistance (AR) genes come with negligible costs to the bacteria, so do not suffer from negative selection. 2) They are often encoded on extrachromosomal transposable genetic elements (e.g. plasmids) or like the MecA gene in Staphylococcus aureus can be transferred by viruses - so you cannot prevent the spread of AR genes between your susceptible and resistant strains. 3) AR genes often, through selfish gene mechanisms, get crowded onto plasmids or prophage with other genes that confer a net benefit, such that they can piggyback on the positive selection of other genes to proliferate. 4) Resistance mechanisms like multi-drug efflux pumps, efflux many many other cytoplasmic contaminants, such they provided a benefit to bacteria in a wide array of environments. 5) Over 80% of antibiotics produced in the developed world are used as growth promoters in agriculture, rather than therapeutics. Therefore most of the interaction between bacteria and antibiotics is happening in the broader environment, not in the clinic. 6) Continuing from above, most of your patients present to the clinic having already acquired the resistant infection in the broader environment, so bacteria in the clinic are unlikely to have a positive impact. Dusting yourself with Staph/Klebsiella/Salmonella/Cholera etc, resistant or not is a terrible idea. You would wind up with far higher rates of infection and subsequent morbidity as a result, with a net negative public health outcome.
  8. 1. God is omnibenevolent 2. God collectively punishes humanity with genocide. Pick one.
  9. If this is true, God let Nero, Genghis Khan, Ivan the Terrible, Stalin, Hitler, Pol Pot, Pinochet, Mao, Osama Bin Laden, Ferdinand Marcos, Idi Amin, Franco, Saddam Hussein, etc etc etc happen. Political leaders and regimes who literally murdered millions of people Why would the divine intervene in the 2016 election?
  10. Significantly confounding problems with the simplistic approach you've taken include that mutation rates are not uniform between species and across genomes https://www.nature.com/articles/nrg3098 and that the number of observed mutations is proportional not just to mutation rate, but population size also https://www.ncbi.nlm.nih.gov/pubmed/17348929 Usually, to calculate time to most recent common ancestor (TMRCA), you'd use a molecular clock mutation model and a bayesian MCMC analysis to generate posterior probabilities. This article has a really good explanation of methods to calculate TMRCA https://www.genetics.org/content/158/2/897.
  11. Strange already explained it, but the opening post sounds an awful lot like an irreducible complexity argument, and the factual errors, lack of citation and flawed analogies are archetypical of such arguments. To clarify, I'm not accusing you of religious motivation - but the opening post sure looks an awful lot like the standard lead up to a creationist pitch, which might explain some of the reaction you're getting.
  12. You mean aside from the extensive discussion of regulatory function. Most of the eukaryotic genome does not encode amino acids. The original post failed spectacularly because it was riddled with factual errors and stank of religiously motivated creationist tropes.
  13. Correct me if I'm wrong, but it seems like you're saying the "missing" information is that gene products conform to the scientific laws of nature in order to form biological structures... or are you implying that some unknown, supernatural other organizing force is necessary?
  14. On its own - no. You brought up Hox genes in the context that the diversity of Hox genes did not account for the diversity of observed body plans. I simply presented the considerable body of empirical evidence which demonstrates that they do explain that variation. I hope this stems from a lack of understanding rather than disingenuity - but the proximity of a regulator to other coding genes dictates its effect in a regulatory cascade - no one should expect the Hox gene, or any other regulatory gene to self determine its regulatory function - genomic architecture dictates the genes downstream of a regulator. Hox genes are part of a regulatory cascade that does determine which proteins are expressed in cells, and how they differentiate spatio-temporally. They are part of the genetic system that governs "how millions of cells with different patterns of gene expression work together to create a morphological structure". I certainly did not state that Hox, or homeobox genes in general explain everything - that's a considerable strawman. "A diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation, all concur to control Hox gene outputs." https://dev.biologists.org/content/140/19/3951.abstract And here we go down the rabbit hole of shifting goalposts and argumentum ad ignorantiam. No one ever claimed that Hox genes in isolation explain the diversity of the tree of life, all of developmental genetics and the entirety of tissue differentiation. They are adequate to explain animal body plan variation, as shown by significant, already cited empirical evidence. The claim that they demonstrate a gap that genetics cannot explain was therefore false.
  15. From your own citation: "Evidence in support of this last hypothesis has come from recent studies which document the overlapping function of different Hox genes [18], [19], and comparative studies of expression patterns in a number of crustaceans and insects [13], [14], [20] which support the idea that changes in Hox gene regulation may be responsible for the diversification of body plans and the generation of new segment types." Substantial research over the last 20 years has elucidated that spatio-temporal variation in Hox gene regulation and protein plasticity allows for an extraordinary array of body plans from the same ancestral set of homeobox genes. e.g. "A considerable body of evidence suggests that evolutionary changes in developmental gene regulation have shaped large-scale changes in animal body plans and body parts. In particular, many comparative analyses of Hox gene expression in arthropods, annelids, and vertebrates have revealed a consistent correlation between major differences in axial morphology and differences in the spatial regulation of Hox genes." https://www.cell.com/fulltext/S0092-8674(00)80868-5 https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201600246 So, no, it supports the idea that developmental genetics underlies morphological diversity in the animal kingdom.
  16. I appreciate you've though deeply about this issue - however this is incorrect. Regulatory genes can, for example, encode silencing mRNA which is used for post-transcriptional regulation of gene expression. RNA secondary structure can act to alter gene expression. Somatic V(D)J  recombination of existing genes is critical for adaptive immune function. There is an entire field of Developmental Genetics which deals with the mechanisms for differential expression during development - and the vast majority are genetically determined. Ultimately, the genome does a lot more than simply encode proteins, and much of its less obvious function is newly and incompletely understood - the term "junk DNA" was coined in 1972 to describe the 98% of the human genome that does not encode proteins. It wasn't until the 1990's that we started to unravel the function of non-coding DNA, but it does a lot more than we originally thought and were are still in the process of determining its function.
  17. Given the ubiquity of microplastics (e.g. https://www.nature.com/articles/s41559-017-0116), I think the horse has largely bolted regarding plastic pollution. A layer of microscopic plastic covers the planet, to the extent that detection of plastics in sediments is a key indicator of the Anthropocene. Microplastics have been detected in significant quantities in the bodies of crustaceans living at the bottom of the Mariana Trench. Furthermore, entire oceanic ecosystems have developed in association with large ocean garbage patches. We risk further impact on already declining abundances of oceanic organisms if we decide now to retrieve oceanic plastics. That's not to say we shouldn't reduce continued plastic pollution, but the problem has advanced to the point where simply cleaning up the mess is not so simple.
  18. I'm not sure why it would offend you - Homo sapiens is simply not very unique compared to other vertebrates by any biological measure - we have anatomical, physiological and genetic homology with other vertebrates on earth. The evidence for shared ancestry of humans with other vertebrates is very strong. Also, we have confirmation bias when it comes to recognizing environmental change we cause - we tend to notice the things that appear most different to us, which tends to be the deliberate changes we make to our environment. Aside from the classic example of the impact of photosynthesis on atmospheric composition, rinderpest virus dramatically altered the entire forest structure and ecology of sub-Saharan Africa in a matter of a decade http://oxfordre.com/africanhistory/view/10.1093/acrefore/9780190277734.001.0001/acrefore-9780190277734-e-375
  19. http://lmgtfy.com/?q=black+holes You asked for advice to improve your somewhat meaningless internet reputation score and now you're arguing with that advice... that's probably not going to help.
  20. Posting single line question after question on the forum is spammy, low effort and annoying. Try researching a topic yourself and offering some discussion instead of expecting others to do all the work for you.
  21. Undoubtedly the pharmaceutical industry has to shoulder some of the blame for the public mistrust in them - I mean, the link between opioid prescription and industry payments to doctors is pretty solidly established. There is a deep rooted problem in capitalizing healthcare and medicine which is particularly pervasive in the US. However, this is doubled up by actual conmen and snake oil salesmen taking advantage of that mistrust to defraud people - which is how the anti-vax movement started.
  22. When anti-vaxxers will prefer to believe a former Scientologist who literally claims to be an alien god when he tells them to put industrial bleach up children's backsides to cure their autism, there isn't much hope for logic.
  23. That's certainly the position someone like Francis Collins takes - ID proponents like Behe argue that life is irreducibly complex and natural mechanisms are inadequate to explain it, meaning that there HAS to be supernatural involvement beyond simply kicking it off.
  24. So looking at the image below, it appears that Galagidae have recognizable soles, but Cynocephalidae do not : and when we look at a primate phylogeny, we see the split between these two groups is around 65 million years ago: So soles originated about 65 million years ago, give or take. You meant soles as in soles of the feet, right?
  25. Apologies, I misinterpreted and thought you meant a few weeks in the literal sense, and yes, I knew that - I was making an analogy to a well established scientific theory and an inappropriate alternative hypothesis rather than trying to directly comment on your own example. The point was that evolutionary theory does have plenty of alternative mechanisms and hypotheses - it's just that ID insists that none of them are adequate and there HAS to be a supernatural explanation. It's not really the case that it is one explanation or the other.
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