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Everything posted by fredreload

  1. Sir, Hi, I will answer the above questions. 1. The dendrites should be modified because they inject RNA into the sea snail's brain(RNA->change gene expression in cell), which is likely to modify the gene expression and epigenetics of the neurons. They however, went on to speculate that the nucleus is doing the work in which they did not examine the changes in dendritic wiring. The proof I want is that RNA modifies dendritic wirings because of epigenetics, that way you can change the number/length of dendrites through different pathways. The article is posted below. https://www.sciencealert.com/memory-transferred-between-sea-snails-rna-engram 2. Well this article I found suggested that the dendrites grew back after they cut it off in drosphila neurons(sorry I can only find drosphila example). The article says that there is a different regeneration pathway for axon and dendrites, but this is not the point I want to prove. The dendrites regenerate suggesting that the epigenetics keep a backup of the structure of the dendrite's length and numbers. Of course the dendrite could have as well grew back anew from the neuron, but they used the term regenerate, and I am unsure on the time frame it took for growth vs regeneration as well. I read a few years ago that the epigenetics supposed to hold a record of the length and numbers of the dendrites, but I've long since lost that paper. Epigenetics is more of a new field for me, I interpret it as a different way of gene expression. Below is the article for dendrite regeneration. https://www.sciencedirect.com/science/article/pii/S2211124713007675 P.S. My eventual goal is to use optogenetics/pathways to remap the entire brain, dendrites and synapses.
  2. Well, I try to find the best solution on Google, but there are all kinds of saying and research including epigenetics, and the research on ncbl which is technical yet complex at the time. It is a bit hard for me to just find a research on such as if epigenetics determine the number of dendrites presented on a neuron. The closest I found is RNA modification in the brain on Sea Snails. Which in terms should modify the dendrites because the sea snail's behavior changes, but they did not go over dendritic changes at all. I did find and is pretty sure on the synapse formation from Glutamate or GABA signaling. So the only thing I am unsure on is the dendritic growth which has been clarified thanks to you else I would probably have to go over the sea snail article again( I can't believe they did not analyze the dendritic patterns afterward). And as a record it does seem like the neuron's DNA holds a record of the dendrites because the dendrites, once cut, could easily be regenerated.
  3. Good call, the neuron does generates its own electrical signal due to ion imbalance when it is just born and is not connected to other neurons. I speculate.
  4. Hmm, I think the dynamic process is correct about dendritic growth, but when the embryo first form, does the dendrite randomly branch out in all directions from a neuron? Why does it branch out 5 dendrites instead of 4 dendrites, what is governing this? This is an image example https://sapienlabs.co/dendrite-complexity-and-intelligence/
  5. I'm thinking of two pathways. One that increase the number of dendrites on a neuron, and another decrease the dendrites on the neuron. I mean you don't just stick a gum onto a neuron to form a new dendrite. The neuron comes with a fixed number of dendrites and it is up to the gene expression to change the number of dendrites it branch out from the neuron. Now when dendrites touch each other, it form synapses. I am not sure if my speculation is correct but do verify this for me Strange. Thanks in advance.
  6. It is alright, thank you for taking the time to read my response. I understand the rigidity of science and thank you for your patience . Sincerely, fredreload
  7. Hi sir, the only reason I look into the genetics of the brain is because I am curious about swapping consciousness. This might be a bit jumping the gun as it is way ahead of the topic, but I find that you sir, might have the knowledge to interpret such a thing. To begin with, our consciousness stays with us throughout our life. And as we fall asleep, the nerve electrical signals retract to the brain stem in a hibernation state. Therefore, I conclude that the consciousness region of the brain must exist inside the brain stem, based on a scientific paper, which sort of rules out the entire cerebellum. Now, to go one step further, let's take a look at the brain stem. A brain stem consists of multiple nucleus form from groups of neurons. The nucleus, from my speculation, resembles that of a ping pong ball. And it is from the repeating rhythm of the nerve signals running within this ping pong ball that generates a soul, a consciousness. Watch the video below to get a sense of rhythm based on the brain wave. Now we all know that a nerve signal running in the neurons generates an electric field like a capacitor because of the opposite polarity of sodium and potassium inside and outside the neuron. This means this ping pong ball of consciousness has an electric field emanating out in all directions like a light bulb. Now, what distinguishes a consciousness from another and makes it unique? If you look at the ping pong balls, they all look the same, but clearly they are of different consciousnesses, therefore I must rule out the possibility that the shape of the nucleus(group of neurons) of ping pong ball is the key to the uniqueness of consciousnesses. This means someone could have a cylinder nucleus head or pyramid nucleus head, no I ruled all that out. (But I have to note that the shape of the brain might have an implication on the generation of the resonance of consciousness, the shape of the brain might not constitute the uniqueness of the consciousness, but it does matter on constructing a consciousness). Then what is the difference between the two ping pong balls of consciousnesses. Based on the property left of a neuron, it must be the axon length and the synaptic delays. Since you have just ruled out the idea of axon length, based on the nerve signal traveling speed of 150m/s the distance of axons should be of marginal differences to consider. That leaves the rhythm, the synaptic delays as the key to the uniqueness of consciousnesses. Now could two neurons coming from two different genetics generate the same synaptic delays. This would be the key to mind uploading as you match the rhythm from one brain to the next. Clearly if it is of an identical clone or twin of same genetics I could match the synaptic delays with ease. But if you cross reference it to a different individual, could the same synaptic delays be built on the neurons thereby matching the rhythm of two ping pong balls and consciousnesses?
  8. Well let's compare a single neuron. The axon length is mostly the same for the two I speculate, or does it differ between male and female? Can you also get the same synaptic delays for the two neurons for male and female(i.e. the delay time traveling from neuron to neuron).
  9. Yes master, right because everyone's genetic is slightly different based on height and size, but that shouldn't affect the cells being the building block of the body, maybe the pigment. Of course to prove whether you could get the exact same synapses of two neuronal cells with different genetics is still in debate. But if synapse is an attribute of the neuronal cell type, it should hold true unaffected by the genetics. I am not sure about pigments though, as it constitute different eye colors and hair
  10. Question: Person A and Person B has different DNA. If you are to match person A's neurons and synapses with person B's neurons in structure and synaptic delays is it possible?
  11. Ranging from dinosaur to your neighbor, what is the DNA samples you wish to get your hand on? 1. Myself 2. My mom 3. My cat 4. My neighbor
  12. Alright, enough joking. There are two types of mutations. 1. For muscle dystrophy or color blindness because of a single letter genetic mutation. Sometimes they send in the crispr to fix that one single letter for proper enzyme production. What I assume is that once the letter is switched, the correct enzyme begins to produce without having to proliferate(regeneration). 2. This is from speculation(I guess it really doesn't belong here = =). If I swap all the chromosomes in my body with the bear's chromosome, which is considered a mutation. Do all the cells in my body gets converted to bear cells automatically? Do the cell's identity changes because I swap the chromosomes in the nucleus? Human cell + bear chromsomes in the nucleus = bear cell? P.S. I think it is possible, question answered, thanks
  13. We've all seen x-man right? What's the chance of that happening Charon?
  14. No no, you don't add water with bread, it just makes it soggy. What you need is a heating element, refers to the browning video up top, and of course you put it on very low setting maybe higher than defrost. One that potentially allows you to bake bread in the microwave Right, I want to add that the idea is not on speed, for steak and larger chunk of meat it needs to be in low setting for at least 10min or longer. If it takes 3 hours in a heating oven, than it could take just as long in a microwave. The trick is not on speed, but on how well done this steak could get. And I found a funny April Fool video on steam microwaving. Just for amusement. Thing is this could be doable in the future, but even at defrost setting the meat might still get overcooked. One inch depends on the wavelength of a microwave right , beats me lol. I think You need to set it at lower setting and for longer to allow the heat to transfer for larger chunk of meat.
  15. The idea is that, microwave is supposed to work like a oven. That you can use electromagnetic radiation to slowly heat up a big chunk of meat. If defrosting the meat is an option then we know that the microwave frequency can be changed to do this. The result is just how well this microwave(x-ray?) should be designed so that it does not just heat up one side of the food and has a shorter or longer wavelength. The nutrition of the food does not get lost, from what I've read microwaving is supposed to be even more nutritious being that the flavor is not lost. It's just that we use it to cook left over food all the time and the tomatoe turns out kind of soggy :D. That is to say if I can throw in some raw chicken and get BBQ wings in the microwave after a few hours, I might still order it from Dominoes
  16. Ya well, my mistake, you need a heating element in the microwave. This one demonstrates it. Apparently a material capable of absorbing microwave to create a browning effect. P.S. I dunno why it's upside down, but this goes for a pretty good auto cook machine It's sort of an idea on how to cook the perfect steak. You put it in an oven for a few hours, than you brown the outside.
  17. I agree with you. But what I have in mind is that the microwave supposedly heat the food by water molecules. If I have to cook a turkey and I have to choose between roasting it in an oven or heating every single water molecule to an even temperature(probably an expensive microwave), the later one sounds like a good choice as well. As for browning. I might get one of this
  18. Why isn't microwaving the perfect way to cook? What is the down side?
  19. My parents order gas for the duration of the cooking days, but then now I got interested in blow torch cuisine, so I'm like, why do we use gas fuel instead of blow torch which uses a liquid fuel? Btw which one is safer, I am afraid it might blow up on my face
  20. Agreed, thanks for the clarification sir P.S. Reconstruction?
  21. The way they construct the image with fourier transform is based on signal strength I think(this is based on speculation). The way MRI works is first you fixed the position of the water molecules with a magnetic field, send a radio wave to it, then receive the radio wave bounces back from the water molecule with a receiver. Now you dunno where the water molecules are, but you will know the signal strength this water molecule would receive. You already solved the water molecule's position when you generate an image using the fourier transform, that is how you get an image out of the water molecules position. As for the signal it is meant for wireless communication with nanomachines. But a nanomachine isn't polarized like a water molecule so. I dunno what sending a desired signal to the water molecule could be applied to
  22. At one end, the receiver picks up the radio wave and construct an image. To reverse it you create a transmitter and reverse the fourier transform to pinpoint the water molecules to communicate with the water molecules
  23. I call yellow water turn yellow. Or glow in the dark. Or electric shock
  24. First of all, I want to know how the scientist distinguish whether a virus have injected the enzyme of their target into a cell. For instance Crispr, you only need one virus to deliver the package into the cell, not two, and definitely not more than that. So how does the scientists control such a mechanism in which the virus only deliver their cargo into the cell once? Apart from this question I want to open more opportunities as to how nanomachines could act like cargo trucks for delivery within our body.
  25. 1. Dreams 2. Well if you've been following the Salk's method of reverse aging on rats then you'll see that they've managed to extend the lifespan of the rats from 22 weeks to 29 weeks. They use the Yamanaka factors activated by the Tet Casette method to enable and disable the Yamanaka Factors with doxycycline. But they use it involving the oncogene Cmyc so it might still proliferate all the cells in the mouse, so in the end I think I would go with the three Yamanaka Factors and depleting Mbd3 for 100% success rate. Keep in mind this is partial reprogramming, if you go all the way it would cause teratoma. Now my other idea is to apply progesterone to the entire body after partial reprogramming thereby ensuring proper patterning to the entire body. But as of the present time we have not created a proper tet casette method for human, the best we got is the use of hormones for overexpression and lower expression of the Yamanaka Factors, and we are unsure of the dephosphorylation mechanisms. So, they are thinking of the virus method, the delivery method is still uncertain. Now if you are thinking of gender bending with a potion you will have to manually swap in an X chromosome and disable the Y chromosome using a bacteria. After which the entire body contains a pair of X chromosomes you would then intitiate regeneration again using progesterone for proper patterning to the entire body.
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