PhilGeis

Microwave treatment can indeed kill bacteria tho' a brief exposure such as heating yogurt prob will not eliminate all viability. Be aware - microbial populations in commercial yogurts are unstable and decrease of viable counts are common to the point that claimed benefits are more hype than substance.

Review - notes value in combined therapy - bacteriophage and antibiotic. Suggest folks remember their virology lab with bacteriophages and E. coli from sewage - the ease with which resistance was demonstrated

antibiotics-09-00135-v2.pdf

Please - let's not invest political bias in the discussion. Suggest you drop the ad hominem and read the assessments. Thanks for the critique editorial.. Afraid most of it is similarly ad hominem. What metrics would you think best to estimate impact of lockdowns? the articles included deaths per capita by state, in school days lost and economic impact. Flatten the curve 'til vaccine was the original purpose but infection rates are tough to see valid as reporting enjoyed no protocol and most likely went unreported.

https://www.nber.org/papers/w29928 https://sites.krieger.jhu.edu/iae/files/2022/01/A-Literature-Review-and-Meta-Analysis-of-the-Effects-of-Lockdowns-on-COVID-19-Mortality.pdf4 "While this meta-analysis concludes that lockdowns have had little to no public health effects, they have imposed enormous economic and social costs where they have been adopted. In consequence, lockdown policies are ill-founded and should be rejected as a pandemic policy instrument."

No. Just run an MIC.

Good point. And the mRNA-based vaccines ever more of a focused magic bullet.

Perhaps antibody therapy for relevant cancers https://pubmed.ncbi.nlm.nih.gov/22437872/ and https://www.criver.com/eureka/magic-bullets-the-next-evolution-in-targeted-cancer-therapy and the term has meaning in the history of micrpbiology https://www.smithsonianmag.com/smart-news/syphilis-cure-magic-bullet-180964644/

My comments addressed omicron strain.

The stated purpose and function of this vaccine and its controversial mandates is to address the pandemic. No - it does no mean effective immunity. There is an association with reduced morbidity and mortality. Coincidence is not cause and assuming "immunity" is not justified. Numbers are not normalized

The vaccine vs omicron is apparently useless as a "vaccine". Reportedly is associated with better outcome in morbidity and mortality

Covid has a high mutation rate - up to 10X greater than the already high rate of RNA viruses in general. Mutation shows the limitation of current mRNA based vaccine technology - so narrowly focused, variants move out of efficacy range. Tho' justified in part on the rapidity of development and warranted as you say by variant generation, it still takes too long to develop and administer. Appears there is no attempt to develop.

https://ufonline.ufl.edu/degrees/undergraduate/microbiology/

Wonder at the stats for this. With vaccine(s) showing efficacy in mitigating morbidity and mortality rather than infection and the dynamics of variant expansion, to what extent would broader vaccination constrain variant generation.

Waiting 15 minutes is conventional and is driven by the majority of reactions observed and the practical aspect of maintaining folks cooperation. but certainly does not indicate absence of subsequent reactions, including a anaphylaxis. "Symptoms of anaphylaxis often occur within 15-30 minutes of vaccination, though it can sometimes take several hours for symptoms to appear." https://www.cdc.gov/vaccines/covid-19/clinical-considerations/managing-anaphylaxis.html Where any reported subsequently? Was there a means of reporting >established for the vaccinated after exit? What was protocol for treatment - epinephrine? antihistamine? What was "successfully treated"? Recall anaphylaxis may manifest in those appearing to recover. How long did those folks stick around?

Poor surveillance reports anywhere - are poor reports. What was origin?

What does FDA have to do with this? It approves the vaccine and monitors and potentially responds to adverse repot data - https://vaers.hhs.gov/ . It would find comments such as -prob would happened anyway - and prompt and successful treatment - pretty poor. Any report would include qualification of those monitoring, whether active or passive, period through which monitoring was effected, voluntary reports from vaccinated after monitoring, specifics of reactions observed, how treated, criteria by which resolution was determined, etc. What protocol that? In any case, relevant protocols do not suggest - they are methodology. Clearly there are can be post release reactions - https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/reactogenicity.html

Everyone was observed while present, beyio Everyone was observed for a time - beyond surveillance addressed time. Adverse reaction may not be within time of survelliance. I jumped to no conclusion. Prompt and successful is subjectiuve and would not be appropriate description for reporting adverse reaction to FDA.

Doesn't change the conclusion of very rare reaction - but -an overly favorable summary. Adverse reactions are not reported in this way. Three should be reported as those observe not absolute. Reactions may have been experienced beyond surveillance. "Likely would have happened", "nothing to do" and "promptly and successfully treated" are overly-favorable speculation.

Think this is the paper by Lednicky et al. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab924/6413759?login=true - you can download the entire pdf. It's always a good idea to read the actual report if possible rather than taking second hand interpretation from media. They did not say it (viral RNA from one sample) was the same virus but that it was closely related to Vlasova et al. Malaysian virus that appeared to be ancestral. So an interesting journey - and/or maybe recombination in the one host. "We report here identification of a coronavirus of canine origin which is closely related to the Malaysian virus reported by Vlasova et al, albeit isolated in this instance from a visitor to Haiti, and with a further recombinational history." RNA viral mutation rates of 10E4 to 10E6 and coronavirus rate is reportedly much greater. It's not just limited to the existing genome but is extended by recombination. ".... Vlasova et al reported isolation of an Alphacoronavirus of apparent canine origin, with evidence of recombination with a feline coronavirus, from patients with pneumonia in Malaysia [6]. "

Behavioral measures at the individual level do not prevent - they mitigate risk. As mandates, they may have an initial impact but have not been successful even in the moderate term for the reasons you point out. They chip away at nothing.

Spread is at best transiently impacted by masks etc. - and even less so with the delta variant. They will not "keep infections low". It's merely a matter of time until a population experiences its surge. At the personal level, one may reduce risk, esp. transiently, with masks etc. At the macro/mandate level - these have not been that effective and prob even less so now with the more infective delta.

The disease will progress through unprotected populations. To the extent there is an effect re. masks, banning mass gatherings, distancing etc., it will be transient and certainly less effective vs delta than the questionable impact on the initial strain. Vaccination is the most effective control measure for limiting infection and exp. severity of disease.

studiot - viral "evolution" is the result of mutation and selection. Washing with soap or surfactants disprupts an essential general element of the virus the basic structure of the lipid coat - mutation in that aspect would be lethal. "Chemical" - assume you mean alcohol, hypochlorite and other disinfectants. These have similar primary and general denaturing effects. In any case, these factors would be less than de minimis in context of a global pandemic where mutation and potential selection are constant and exponential.

To the orignal questioin - washing hands and "chemicals" will not drive variant development.