PhilGeis

Here's a link to Enthalpy's article as published. https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v1.full.pdf?__cf_chl_jschl_tk__=a86b2dd74b9552d1d4f20a7864035bd659d7cab3-1584459780-0-AQvqZdHHCaPow7_aaVyOciisxEsFxWD7dt5LxZz9yFnctl19BJBIuXBcPM5A9ozQtN76r8AbM2OxyT-6jdSNOUKeza-1Xmh5mxDa16U1p2Tpzu-blP6XlUI4lOv1zjDbQeV_687uWYZ3Ai5azCdkigYIOW58LDlm9eJebevJCExQJJ5dhc0SW7O6V1OxW-1oxoI5hVuyCoI7kx_0tzshxPwkyPPzurSHOPt83t9ApuIKJyfOxyRV8rG12b9eQPd1EoUzpOT2RuxRMuzC3soObDxDMd2FhWrKmDbRBQutfEOetdr8-LahRy3d2rkVg9vHpNtm6BdmBcD5wXLShkl7Ltg

Yes CharonY - was referring to this paper it's authors fulfilled their expectation based on prev data such as you mentioned.

Please read the protocol and results as well as the conclusions. Published or not, it has some flaws. As can be seen with the top graphs, inconsistent challenge inoculum titers and more importantly LOD's biased (by about a log) in favor of copper treatment. If cardboard had the same LOD, it would appear nearly as effective as copper.

Thanks Phi A significant but trivial change in platelet count (treatment v control) was observed but was not shown to be clinically relevant. As authors noted - There is still no specific treatment for dengue. This publication does not appear to support your excitement for papaya juice. What in this study did you see as compelling? Methods are so poorly described that it would be impossible to precisely reproduce this study without contacting authors for more information. We don;t know papaya juice dosing parameters or how platelet were counted. 1) Dosing and relevant testing were not made clear. " Patients in the intervention group received fresh juice from 50 grams of C. papaya leaves, once daily, 15 minutes after breakfast for 3 consecutive days." I guess we can assume intervention group subjects drank the juice but we do not know when 48 hours of blood testing was initiated relative to consumption. 2) The critical parameter evaluated was platelet count and NO method was identified for this analysis. Only "The haematological and biochemical tests were conducted by the Pathology Department at Hospital Tengku Ampuan Rahimah, Klang and the validated results were later traced and recorded." MORE Importantly - Results are not compelling 1) Authors noted "Study on the treatment effect of CPLJ on platelet count regardless of time did not show any significant difference in mean platelet count between intervention and control group." However, if they dissect time point they did find what in effect was a trivial difference. " However, analysis of the effect of CPLJ over the study period (time and treatment effect) showed that there was a significant interaction between treatment groups and time." 2) . Normal platelet counts are 150,00-450,000 per microliter. This report refers to platelet counts but offers no number per any volume. Fig. 1 reports platelet counts as a simple number (no volume identified) difference of treatment v. control. There was trivial difference between 1 hour and 40/48 hour time points although authors managed to find a significance in comparison of 0 and 40/48 hour v control. Look at Fig 1 - 1 hour is really not that much different than 40 and 48 whatever its statistical difference.

Think the evidence is a bit weak to support " Consumption of papain leaf extract can probably help in fighting Covid-19 infection..." Ahmad (2011) rported in a pretty obscure journal treatment of a single patient observed minor CBC changes and "patient feelings" and Kumar et al (2015) reported statistically significant but minor CBC changes and observed treated patients (there was no apparent control group) "started to recover". Pandey et al. (2016) offered a literature search for antiinflammatory and immunomodulation citation with ""papaya" and concluded "Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking." Did not see that they addressed dengue as implied above. Norhamad et al. 2019 saw change in cytokine level -with papaya leaf extract fed infected mice, did not see a reported therapeutic benefit. observed in the paper Papaya extracts may have anti-inflammatory and immunomodulation efficacy - that does not translate to cure of viral disease - esp. coronavirus for which there re no data.

Vaccine would derive from the infectious agent - not the now immune individual. Another "host" is not going to replicate foreign antibodies.

I recall temperature screening upon entry at airports started with SARS and is still in place in China and some SE Asia countries. Short of Cobalt 60 insertion for gamma irradiation, the elevator is not going to be "sterilized" hourly or at all.

Please calm down Sensei. One can be aware of the statistics without being anxious and being aware serves no purpose. What are you doing about it other than worrying?

Agree - draconian projections (from AB resistance to climate change) that folks don't eventually observe in their daily lives drives to skepticism. I'm with dimreepr - what's for dinner?