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gib65

Can you become tolerant to your own neurotransmitters?

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Can one become tolerant to one's own neurotransmitters? I know this can happen with a drug like dexedrine. Dexedrine increases the supply of dopamine in the synaptic gap, and based on my own experience, one can develop a dopamine tolerance at these sites. But what if you were in an environment in which you were being constantly stimulated by things which resulted in dopamine releases in the brain. For example, what if you were a video game addict. I'm told that the joy of playing video games comes from all the little dopamine releases that the game provides. Would you develop a dopamine tolerance even then? 

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Isn’t this just desensitization? 

Also, CNS fatigue?

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Desensitization refers to neurons getting tired of firing. It happens over the course of minutes. They just need to rest for a few minutes and they are ready to fire again.

Tolerance, on the other hand, is the process by which neurons attempt to adjust to over- or under-stimulation by increasing or decreasing the number of receptors being stimulated. This happens over the course of several days or weeks, and takes about a week to recover from.

Here's a link: https://www.pharmacologyeducation.org/pharmacology/desensitisation-and-tachyphylaxis

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