ritastrakosha

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About ritastrakosha

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  1. Can you support the statement "you are a moral crusader" with facts? So as we are scientific here :-).
  2. Michael Bailey, a renowned sexologist, has recently written an opinion article in the Archives of Sexual Behavior, titled "How to ruin sex research". He writes that sex research is being hampered by ideology and scientists should not bow to ideology. He urges for the controversial ideas in sex research not to be censored. Quote: If people knew which ideas had merit and which did not even before the ideas had been thoroughly discussed and tested, then we would not need science. What do you think?
  3. Could this also happen to humans? Sci Rep. 2019 Mar 18;9(1):4837. doi: 10.1038/s41598-019-41258-2. Prenatal Allergen Exposure Perturbs Sexual Differentiation and Programs Lifelong Changes in Adult Social and Sexual Behavior. Lenz KM1,2,3, Pickett LA4,5, Wright CL4,5, Galan A6, McCarthy MM4,5. Author information Abstract Sexual differentiation is the early life process by which the brain is prepared for male or female typical behaviors, and is directed by sex chromosomes, hormones and early life experiences. We have recently found that innate immune cells residing in the brain, including microglia and mast cells, are more numerous in the male than female rat brain. Neuroimmune cells are also key participants in the sexual differentiation process, specifically organizing the synaptic development of the preoptic area and leading to male-typical sexualbehavior in adulthood. Mast cells are known for their roles in allergic responses, thus in this study we sought to determine if exposure to an allergic response of the pregnant female in utero would alter the sexual differentiation of the preoptic area of offspring and resulting sociosexual behavior in later life. Pregnant rats were sensitized to ovalbumin (OVA), bred, and challenged intranasally with OVA on gestational day 15, which produced robust allergic inflammation, as measured by elevated immunoglobulin E. Offspring of these challenged mother rats were assessed relative to control rats in the early neonatal period for mast cell and microglia activation within their brains, downstream dendritic spine patterning on POA neurons, or grown to adulthood to assess behavior and dendritic spines. In utero exposure to allergic inflammation increased mast cell and microglia activation in the neonatal brain, and led to masculinization of dendritic spine density in the female POA. In adulthood, OVA-exposed females showed an increase in male-typical mounting behavior relative to control females. In contrast, OVA-exposed males showed evidence of dysmasculinization, including reduced microglia activation, reduced neonatal dendritic spine density, decreased male-typical copulatory behavior, and decreased olfactory preference for female-typical cues. Together these studies show that early life allergic events may contribute to natural variations in both male and female sexual behavior, potentially via underlying effects on brain-resident mast cells.
  4. I answered you on that. Vaccinations have decreased epidemics but not to the extent that is claimed by the pharmaceutical industry. The decrease in infectious diseases began before vaccine use became widespread.
  5. I don`t understand you. What ideology? One way paracetamol is thought to contribute to autism is by depleting glutathione, which detoxifies (aluminum among others). Paracetamol is given after vaccination.
  6. So you say that a population where let's say 10% of the pairs are homosexual and 90% of the pairs are heterosexual the family is stronger and children better cared for than in a population where 100% of the pairs are heterosexual. Homosexual pairs are not better equipped than heterosexual pairs to raise children. It would be evolutionary better for children to be raised by male-female pairs instead of male-male or female-female pairs. Millions of years of evolution have led to female-male pairs being the norm.
  7. It is under review. Yes, there is plenty of homosexual behavior, like there is plenty of different kinds of behavior. So, what? 2000 years of brainwashing seems a long time. I know about causation and correlation. The study has addressed this by explaining at the physiological level how stress leads to homosexuality. I am an atheist.
  8. Another interesting thing is, why are you so obsessed with psychology and psychiatry to be a member of this forum? Keep focused on the question. The answers to your dilemmas are in the study.
  9. I mean the injection route is 1 million times more efficient at increasing aluminum content in immune cells. What does the title you cite make clear? Artificial light is a stress source. There is abundant research on this. There are multiple other stress sources linked to homosexuality, whom the journalist does not mention, perhaps because of feeling uncomfortable around them, like drug use for example?
  10. My question is: What do the members of this forum think about the hypothesis that diet and stress cause homosexuality? If they wish to know why I think so, they have all the information in the shared link. The link is to a non-profit science archive. I have to link because the study has over 60 pages of interlinked information and arguments. It has new research and ideas compared to the one I shared last year. There are new studies published all the time on homosexuality. Many scientists see it as researchable, hence discussable.
  11. I was watching an interview with Chris Exley yesterday, who has studied aluminum for 35 years. He said that they haven't found in any other body parts such high levels of aluminum as in the glia of the brains of autistic children. Exceley has also done studies on aluminum and Alzheimer and says that the link is strong. He is not funded by the industry, the states or the charities because there is no money in such study, on the contrary. Meanwhile his study has been downloaded 250,000 times. Vaccines contribute to the decrease of epidemics, but their contribution is smaller than thought (much smaller according to some). In an international science conference on vaccines held in Portugal this summer one of the scientists (Romain Gherardi?) was saying that compared to the injection route one would have to ingest 1 million times more aluminum to have the same accumulation of it in the immune cells.
  12. I have had measles myself. Almost all children got measles at my time. It was like having a severe influenza. It lasted for several days and it was over. Measles causes severe complications in 1 in 2000 children. Taking vitamin A can halve the complications from measles. Today, children with allergies, asthma have to suffer all their life. The decline in infectious diseases began before the mass use of vaccines and was rather due to the improved nutrition and sanitation. You may be interested to read the below papers on aluminum. Around 40% of children in developed countries have an immune disorder today (food allergies, asthma, eczema, autism etc. which are all immune related disorders). Why all this sickness? J Inorg Biochem. 2011 Nov;105(11):1489-99. doi: 10.1016/j.jinorgbio.2011.08.008. Epub 2011 Aug 23. Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? Tomljenovic L1, Shaw CA. Abstract Autism spectrum disorders (ASD) are serious multisystem developmental disorders and an urgent global public health concern. Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. When assessing adjuvant toxicity in children, two key points ought to be considered: (i) children should not be viewed as "small adults" as their unique physiology makes them much more vulnerable to toxic insults; and (ii) if exposure to Al from only few vaccines can lead to cognitive impairment and autoimmunity in adults, is it unreasonable to question whether the current pediatric schedules, often containing 18 Al adjuvanted vaccines, are safe for children? By applying Hill's criteria for establishing causality between exposure and outcome we investigated whether exposure to Al from vaccines could be contributing to the rise in ASD prevalence in the Western world. Our results show that: (i) children from countries with the highest ASD prevalence appear to have the highest exposure to Al from vaccines; (ii) the increase in exposure to Al adjuvants significantly correlates with the increase in ASD prevalence in the United States observed over the last two decades (Pearson r=0.92, p<0.0001); and (iii) a significant correlation exists between the amounts of Al administered to preschool children and the current prevalence of ASD in seven Western countries, particularly at 3-4 months of age (Pearson r=0.89-0.94, p=0.0018-0.0248). The application of the Hill's criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. Aluminium in brain tissue in autism Author links open overlay panelMatthewMoldaDorcasUmarbAndrewKingcChristopherExleya Show more https://doi.org/10.1016/j.jtemb.2017.11.012Get rights and content Under a Creative Commons license open access Abstract Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissue yet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder. Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines Romain Kroum Gherardi,1,* Housam Eidi,1 Guillemette Crépeaux,1 François Jerome Authier,1 andJosette Cadusseau1 Author information Article notes Copyright and License information Disclaimer Abstract Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition. We previously showed that poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in brain. This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity. The understanding of basic mechanisms of particle biopersistence and brain translocation represents a major health challenge, since it could help to define susceptibility factors to develop chronic neurotoxic damage. Biopersistence of alum may be linked to its lysosome-destabilizing effect, which is likely due to direct crystal-induced rupture of phagolysosomal membranes. Macrophages that continuously perceive foreign particles in their cytosol will likely reiterate, with variable interindividual efficiency, a dedicated form of autophagy (xenophagy) until they dispose of alien materials. Successful compartmentalization of particles within double membrane autophagosomes and subsequent fusion with repaired and re-acidified lysosomes will expose alum to lysosomal acidic pH, the sole factor that can solubilize alum particles. Brain translocation of alum particles is linked to a Trojan horse mechanism previously described for infectious particles (HIV, HCV), that obeys to CCL2, signaling the major inflammatory monocyte chemoattractant.
  13. I had some time this summer to work on my previous research on diet, stress and homosexuality, so I put a revised, extended paper "A diet-stress-diathesis model of homosexuality" on PsyArxiv: https://psyarxiv.com/bjxvs/ The paper analyses in detail how the attribution of sexual arousal to a cue, courtship, thrusting reflex and orgasm get affected in homosexuality. The mechanisms of how addiction, brain inflammation, testosterone, estrogen, progesterone, diet and stress affect the phases of the sexual response cycle are discussed.
  14. Aluminium is added to the vaccine to increase the immune response to the virus/microbe. If its effect on immunity would be the same with the ingested aluminium, why bother add it to the vaccine? Infants already have hundreds of foreign chemicals in their bodies when they are born. Vaccines further add to the burden with aluminium, virus and microbe particles. Aluminum vaccine adjuvants: are they safe? Tomljenovic L1, Shaw CA. Author information Abstract Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science's understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue. Slow CCL2-dependent translocation of biopersistent particles from muscle to brain • Zakir Khan, • Christophe Combadière, • François-Jérôme Authier, • Valérie Itier, • François Lux, • Christopher Exley, • Meriem Mahrouf-Yorgov, • Xavier Decrouy, • Philippe Moretto, • Olivier Tillement, • Romain K Gherardi†Email author and • Josette Cadusseau†Email author BMC Medicine201311:99 https://doi.org/10.1186/1741-7015-11-99 Abstract Background Long-term biodistribution of nanomaterials used in medicine is largely unknown. This is the case for alum, the most widely used vaccine adjuvant, which is a nanocrystalline compound spontaneously forming micron/submicron-sized agglomerates. Although generally well tolerated, alum is occasionally detected within monocyte-lineage cells long after immunization in presumably susceptible individuals with systemic/neurologic manifestations or autoimmune (inflammatory) syndrome induced by adjuvants (ASIA). Results Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs, such as spleen and brain where they were still detected one year after injection. Both fluorescent materials injected into muscle translocated to draining lymph nodes (DLNs) and thereafter were detected associated with phagocytes in blood and spleen. Particles linearly accumulated in the brain up to the six-month endpoint; they were first found in perivascular CD11b+ cells and then in microglia and other neural cells. DLN ablation dramatically reduced the biodistribution. Cerebral translocation was not observed after direct intravenous injection, but significantly increased in mice with chronically altered blood-brain-barrier. Loss/gain-of-function experiments consistently implicated CCL2 in systemic diffusion of Al-Rho particles captured by monocyte-lineage cells and in their subsequent neurodelivery. Stereotactic particle injection pointed out brain retention as a factor of progressive particle accumulation. Conclusion Nanomaterials can be transported by monocyte-lineage cells to DLNs, blood and spleen, and, similarly to HIV, may use CCL2-dependent mechanisms to penetrate the brain. This occurs at a very low rate in normal conditions explaining good overall tolerance of alum despite its strong neurotoxic potential. However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier or high constitutive CCL-2 production.