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Genetics

DNA replication, Mendelian Genetics, mechanisms of gene expression, and related topics

  1. BMJ is looking for the next Editor-in-Chief who can continue to shape the Journal of Medical Genetics into the premier resource for geneticists; maintaining the Journal’s high standard for originality and quality. This is an independent contractor position and the term of office is 5 years; the role will take up one day per week. **Application Deadline: Friday 15th December** For more information please read the full advertisement >>

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  2. Started by BadCell,

    So I read that some animals are able to reproduce without a mate and I was wondering what sort of genes these children have? Are they identical to be mother (like identical twins) or are they more like brother and sisters of the mother? Thanks

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  3. Started by wade.daniel.w,

    I recently came to wonder, with genetic code changing with each new reproduction, is it possible our existence as an individual is recreated later down the line, obviously we wouldn't have the same brain or memories (almost like a clone). Also, do any memories get passed genetically (is that what instincts are)? Anyone thought of this before?

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  4. Started by Antwerp,

    Looks like they hit the Hsu boundary (Donoho-Tanner phase transition) and solved the missing heritability problem. https://www.biorxiv.org/content/early/2017/09/18/190124 Abstract We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, ~40, 20, and 9 percent of total variance for the three traits. For example, predicted heights correlate ~0.65 with actual height; actual heights of most individuals in validation samples are…

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  5. Hello, I came to this forum to ask about a personal dilemma I have come across. I am almost an identical version of my cousin. I am female and he is male. Our parent's were very dysfunctional. Most of our relatives (Dads, Aunts, and Uncles) are alcoholics, drug addicts, and among many other things. We were always the best of friends and had a connection. We are pretty much the only two out of our generation that have turned out to be generally respectable people. He has 3 other siblings by his parents. His parents are DAD and MOM, DAD is brother to my DAD and his MOM is married in. He does not look like any of his siblings. He is taller, more thin, he look abs…

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  6. Started by Vii,

    Hello! I would really appreciate your help with this question. If a plant has 48 chromosomes, how many linkage groups does it have, if it is a) diploid; b) autotetraploid; c) allotetraploid ? I know that a) is 24 for sure, but how about the other two?

  7. Started by blt,

    Why hemophilia is lethal (in almost 100%) for homozygotic females, while it's not lethal for hemizygotic males? Both, homozygotic females and hemizygotic males don't have any healthy allel. Thank you for replies

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  8. Can anyone answer it as soon as possible? Let me know more about genetics.

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  9. ¿When and what factors affect the correct functioning of control points in the cell cycle, and how mitosis and meiosis are affected when control points fail?

  10. Making an analogy of the technology with respect to storage devices, as these are becoming smaller and store more information more efficient sienso sienso. Could something similar be happening with the chromosomes?

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  11. Started by dparaguison016,

    In many situation, lot of people experiencing painful condition similar to a migraine that cause them to take different kind of painkiller. if it is not really a migraine, what could it be?

  12. I was curious as to whether or not mutations differ by what they are caused by. Do they? I notice that most mutations {I think} acquired through things like UVA or UVB or certain chemicals just cause cancer {wich is from what I understand, a mutation}. Why is this? Why is cancer so frequent, instead of mutations that do something like change your skin color or the like? Can you, or a plant, or a virus, get a mutation from external sources in the same way as you get them from internal? Mutations are just changes in the DNA right?They are just copying errors or externally promoted, {so I have read}, so I am guessing that their is no difference. Can an externa…

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  13. Started by sebasp,

    In sexual reproduction if half of the offspring (the females) are the ones that produce offspring. Why does sexual reproduction need males? Would not it be more evolutionarily productive that these sexual organisms were females? Darwin explains this with "sexual selection": the preference of one sex for certain characteristics of individuals of the other sex; but this concept suffices to expound the need for male existence?

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  14. Anomalies of the cell cycle such as aneuploidy can occur in a fault in the mitotic spindle where the chromosomes tend to move towards the poles, however I am not clear in which phase can occur this event

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  15. Started by andres felipe grajales,

    The P53 protein is an important regulator at checkpoints against DNA damage. Why is there a high rate of mutation in cells after passage through the cell cycle?

  16. both the cellular adaptability to execute apoptosis and the mitotico weak control points, are easily transferable to future generations ie they can be heritable?

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  17. Started by sebasp,

    There are currently 3 types of reasons for which sexual reproduction has proliferated: 1. Sex helps in the diffusion of advantageous characters. 2. Sex helps eliminate harmful genes. 3 Sex creates combinations of genes that may be more apt than the previous ones. Will the reason for sexual reproduction be universal or will it depend on the species?

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  18. Started by sebasp,

    If species that are hermaphrodite are evidence that sexual reproduction has selective advantage despite the cost (Williams, 1975) could these multicellular organisms explain the passage from mitosis to meiosis?

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  19. Hi All, I am wondering if it is possible to calculate the de novo mutation rate in a genetic disease, given that you know the current disease incidence rate ? Does the de novo mutation rate change over time, as a result of environmental factors etc ? I'm new to genetics so I'm not really sure what plays a part in de novo mutation rates. I can image that if there was an equation, it would take into account many parameters. Regards, Rick

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  20. is there an effect of the mitotic control points on the evolution of cellular adaptations? if such an effect exists, influences a structural change of the chromosomes?

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  21. which is currently known about the structuring and biochemical function of the enzymes cohesin and separase in the cell cycle?

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  22. WHICH PAPER PERFORMS THE DOMAIN OF PROTEINAS BH3 ABOUT THE BAX AND BAK COMPLEX FOR THE ACTIVATION OF THE APOPTOSIS PROCESS. AND IF THERE IS NO CATIVATION OF THESE PROTEINS THAT WILL HAPPEN, DEVELOPMENT WILL BE UNCONTROLLED. ?

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  23. Started by Koni,

    We have 20 amino acids… Each of them can be written with ONE letter: A=Alanine B=… C=Cysteine D=Aspartic acid E=Glutamic acid F=Phenylalanine G=Glycine H=Histidine I=Isoleucine J=… K=Lycine L=Leucine M=Methionine N=Asparagine O=… P=Proline Q=Glutamine R=Arginine S=Serine T=Threonine U=… V=Valine W=Tryptophane X=… Y=Tyrosine Z=… B, J, O, U, X, Z are the 6 letters from the English alphabet which are not been used… We can add this 6 letters to 6 amino acids: A/B =Alanine I/J =Isoleucine N/O =Aspar…

  24. How does epigenetic modification participate in genome stability during the meiotic division cycle and in the processes by which transposable elements control the evolution of the genome?

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  25. Started by Sb89,

    Hope someone can help. I had my child get developmental bloods due to speech delay. The results came back and showed he had an extra gene in a Chromosome. That's all they said. No explanation as to what this could mean. He is 2.5 years and just has a speech delay. Otherwise seems healthy. They want both parents to get bloods to check for same and then go to genetics centre to discuss results. Anyone shed any light on this as I am a little worried. Thanks.

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