Some people have naturally very low reward sensitivity and are less motivated by reward or punishment

In case of neurotic disorders the goal is to strengthen activity in the Prefrontal Cortex and hippocampal neurogenesis with things such as ketamine, allopregnanolone or regular SSRIs even.

How do we do the same with reward system?

You could always try cocaine

7 hours ago, Hans de Vries said:

Some people have naturally very low reward sensitivity and are less motivated by reward or punishment

Not even a high-velocity cookie?