fredreload Posted January 3, 2021 Share Posted January 3, 2021 (edited) So I came across progesterone in a Wikipedia article (https://en.wikipedia.org/wiki/Progesterone) and is interested in how it is actually synthesized in the capsule like Prometrium. The article says progesterone can be derived from diosgenin which can be converted from saponin produced in yam, but I do not think the pharmaceutical companies convert yam into progesterone for their commercial product right? Edited January 3, 2021 by fredreload Link to comment Share on other sites More sharing options...
StringJunky Posted January 3, 2021 Share Posted January 3, 2021 (edited) 2 hours ago, fredreload said: So I came across progesterone in a Wikipedia article (https://en.wikipedia.org/wiki/Progesterone) and is interested in how it is actually synthesized in the capsule like Prometrium. The article says progesterone can be derived from diosgenin which can be converted from saponin produced in yam, but I do not think the pharmaceutical companies convert yam into progesterone for their commercial product right? Your reading the pioneering experiment from 1940, which was a semisynthesis. Read the paragraph underneath that for tthe total synthesis done in 1971. Edited January 3, 2021 by StringJunky 1 Link to comment Share on other sites More sharing options...
fredreload Posted January 4, 2021 Author Share Posted January 4, 2021 12 hours ago, StringJunky said: Your reading the pioneering experiment from 1940, which was a semisynthesis. Read the paragraph underneath that for tthe total synthesis done in 1971. Good call, I did read the total synthesis method done in 1971, it just seems a bit lengthy and complex. Is the total synthesis done in 1971 how they do it in the pharmaceutical companies to derive progesterone? Thanks for your time @StringJunky Link to comment Share on other sites More sharing options...
John Cuthber Posted January 4, 2021 Share Posted January 4, 2021 The implication of what it says here https://en.wikipedia.org/wiki/Mexican_barbasco_trade#End_of_the_barbasco_era is that they steroids are now derived from soy. 1 Link to comment Share on other sites More sharing options...
fredreload Posted January 4, 2021 Author Share Posted January 4, 2021 1 hour ago, John Cuthber said: The implication of what it says here https://en.wikipedia.org/wiki/Mexican_barbasco_trade#End_of_the_barbasco_era is that they steroids are now derived from soy. Good find, but is the method remains unchanged from the 1970s to present? Link to comment Share on other sites More sharing options...
John Cuthber Posted January 4, 2021 Share Posted January 4, 2021 2 hours ago, fredreload said: Good find, but is the method remains unchanged from the 1970s to present? I imagine it will have changed but I couldn't find details. Link to comment Share on other sites More sharing options...
fredreload Posted January 4, 2021 Author Share Posted January 4, 2021 4 hours ago, John Cuthber said: I imagine it will have changed but I couldn't find details. Hmm, I contacted Solvay Pharmaceutical, the company that make Prometrium and they referred me to this site (https://www.carbogen-amcis.com/). I will post my finding if they respond to me through letter Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now