Genetics

Hey everyone. I'm trying to find a program that can calculate LD from dosage data. This has been a fruitless search. I'm trying to prune GWAS results to eliminate loci that are in LD > 0.80 using LD calculated from MY DATA and not from HapMap or 1000G. Any suggestions? Thanks

Hi guys, I am new here, so hello from Utah. I have a question regarding genetics and culture. How much of culture can be traced back as the direct result of genetics? That is: Are there valid criticisms of tabula rasa/blank slate theory? This article is what got me thinking about it: http://scan.oxfordjournals.org/content/5/2-3/203.full I look forward to hearing responses! Best regards, Mo

Hi all, Kindly help me out with this question. Turners syndrome in females occurs due to the absence of one X-chromosome. And we know that in every woman, there is only one active X-chromosome, due to the lyonization process in which one X-chromosome is inactivated. Then why don't all women have turners syndrome, if either ways one X-chromosome does not function (is absent of inactive)?

I have bush outside of my garage door. My father planted it some years ago. It is a horticultural "bush" for lack of a better term. It flowers. The most notable characteristic are the genetically damaged leaves. If you have gamma correct, like NVidia settings it may help to see the photos. I do this things hair up. So bent sticks are probably twisted hairdresser gardening. It was not pruned at the end of last year. Sorry about the darkness. Branch in question is on your left. The offshoot rests on the large offshoot. It should be the one that extends farthest to the left. The bush has one b…

I have a quest about Hfr plasmids. Wikipedia said that you mate an Hfr with an F- plasmid the whole thing transfers over. Is that true. I ask because I would think that the Hfr would be too big to transfer over.

Dear all! I'm working on the following task. Our lab guys have genotyped a couple of SNPs related to a particular disease. I need to reconstruct haplotype blocks consisting of those SNPs. Plink software, http://pngu.mgh.harvard.edu/~purcell/plink/, seems to be an appropriate solution, but I get stucked with it. Still haven't tried other software solutions like Haploview, Beagle, etc... Any suggestions are highly appreciated!

Hi one in 3500 male newborns have DMD how to calculate the mutation rate in the dystrophin gene reponsable of the disease? Thx for your help nayma

I was just taking a test in which there was a question that I found very dubious: "50 people from USA move to a remote island. Which of the following causes the largest change in frequencies of alleles: Natural selection or Genetic drift?" Doesn't it really depend on whether the conditions are particularly harsh on the island or not? Making natural selection more likely the harsher the conditions?

Hi How the LOD score change When we add the penetrance ? its increase or decrease ? please need help to understand that thanks Naima

I just noticed that cats seem to have very close eyes to certain reptiles (mostly snakes and lizards). Were felines and reptiles much close biologically in the past?

I am trying to understand the difference between RNAases and ribozymes. Based on what I have read RNAses appear to be a type of ribozyme whose goal is to control the half life of RNA and to degrade viral RNA. Ribozymes are RNA enzymes that perform both catalytic activity and can act as RNAses. Am I missing anything? Thanks.

when they say that an element or an action is cis-spread along the chromosome what does cis-spread exactly mean?

Here is a title and abstract from a review paper. It mentions that the Snail/Slug family of gene repressors figure in the understanding of the development of cancer. Can anyone explain a bit what the Snail/Slug family of gene repressors are and what they have to do with snails and slugs? A copy of the review paper is attached to this message. Thanks. hemavathy2000.pdf

Does DNA profiling measure two sequences , one from each homologous chromosome ? How is the information used ? thank you

I'm not great when it comes to the sciences, but I joined this forum in hopes that those of you who know about genetics might be able to answer a rather important question for me. I was adopted as a baby and told that my birth parents did not want me. The very abridged version of the story is that a few months ago I found out that my birth father hadn't actually known of my existence. Now that he does, we went ahead and got a paternity test done. The results came back excluding him as my father because four of fifteen alleles did not match. My gut reaction was that something had gone wrong at the lab; I look just like this man, it's uncanny. I began to research and f…

Over the last decade there has been such an advancement in fields related to genetic manipulation. The Human Genome Project results were published in 2001 and that now seems like a distant memory? Only this week in New scientist, Craig Venter is stating that his research team is close to creating synthetic life from scratch (he also stated that the efficiency of biofuel production via metabolically engineered algae has improved 3-fold). Also, how can we forget the instrumental work of Jay Keasling in the same field when he announced the production of an anti-malarlial compound via genetically altered microorganisms. But, it seems like yesterday that GM foods were remo…

Hello Fellow Forum Members, First off I would like to thank everyone that commented on my last post, they were very helpful and educational. Since then I have done quite a bit of research on genetics and the mathematical equations involved, it's been very enlightening and I thoroughly respect anyone who works in this field of science. Anyway back to the crazy creationist arguments.... As I mentioned in my previous post my father is a Jehovah's Witness who rejects evolution and believes that the earth is only 6,000-10,000 years old. He also believes that the science of genetics as it relates to evolution and mutations is false and that he can prove it. Bello…

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I am trying to understand the purpose of DNAses in eukaryotic cells. I think that they are present as antiviral software to destroy single stranded DNA that is floating around in the cytosol and nucleus. However, DNA is single stranded in the nucleus during replication and transcription but those are not touched or few are degraded. Does DNAse have any other functions in eukaryotic cells that I am missing? Thanks.

Hello, I have been wondering about this for some time and unfortunately the math required for it is not exactly my virtue. The question is this: Is the offspring of parents comming from two seperate populations, more likely to have traits of the two parents most recent common ancestor, than the offspring (of the same species) which does not match this criteria? If yes, what is the probability? I understand that the rate of mutation could be a factor so let's say we are talking about long-lived mamals. As said I was trying to figure this out several years ago and the little simulation I ran on it on paper made it look like the probability was rather high (5…

Hi everyone, I am a horticulturalist who is interested in learning more about genetics. In the mean time I have an annoying question to pose, this question comes from my father who is a devout Jehovah's Witness and believes he has debunked evolution and exposed lies in Genetics. I know he is wrong about this and the math he uses to prove his point is a gross oversimplification however I don't know enough about genetics to point out the flaws in his supposed "discovery." Can someone with an elementary knowledge of this please help me? Here it is: "Base Pairs & Math. Your particular favorite sect of evolutionism says that evolution happens very …

Genes for color blindness and hemophilia are linked on the X-chromosome in humans with a recombination frequency of 30%. A woman whose father was a color blind hemophiliac and mother was normal with no history of color blindness and hemophilia wants to have children. The prospective father is normal with no history of either colorblindness or hemophilia in his family. what is the probability that she will have a normal child? 1.) 0.70 2.) 0.675 3.) 0.50 4.) 0.35 5.) 0.30 6.) 0.15 I have to turn it in by 5:45 any help is greatly appreciated

Hello everyone, I have just embarked upon a research project in which I will need to calculate and compare Fst values for SNPs from three or four populations (haven't decided yet, depends on time constraints) obtained from HapMap phase 3. In essence, without getting into too much detail, I am looking for signals of population differentiation that seem to have been driven by selective forces (a particular environmental variable). This project marks a transition from a focus on palaeoanthropology to human evolutionary genetics for me - accordingly, I am a bit of a newbie. Anyhow, to my question. I know how to calculate Fst manually (I have done this for all …

In order to not have an immune response, both the donor and recipient must be RH negative (assuming of course that the recipient can accept the donor's blood)? So if either the donor or recipient is RH+, an immune response will result, correct?

I am trying to understand which of the two operons uses positive and which uses negative feedback. In addition, which of the two are an inducible and which is a repressible system. Would someone mind explaining that?