Jump to content

How can neurotransmitters both inhibit and excite

Featured Replies

That doesn't make sense at all, they're opposite :S

To put it simply, it depends on what signaling pathways the neurotransmitters activate on the postsynaptic cell. This again depends on the type of the receptors to which the transmitters bind. The neurotransmitter themselves have no direct activating or inhibitory activities other than causing conformational changes in the receptor leading to whatever activating or inhibiting signaling cascade the receptor may cause.

  • Author

thank you, i now understand


Merged post follows:

Consecutive posts merged

is there such thing as chlorine channels in the neural membrane? and is the concentration greater on the inside or outside of it when we're talking about chlorine ions. i am thinking if one binded to a chlorine receptor depending on which side is more concentrated it would diffuse and cause it to either be excited or depressed? is this true

The chloride (not chlorine!) ions are higher on the outside than in the inside (the fraction that is relevant for the membrane potential that is). GABAergic receptors are a common class. If chloride channels open it counters the depolarization of the membrane (by allowing chloride influx). That is why GABA is usually a inhibitory neurotransmitter.

Archived

This topic is now archived and is closed to further replies.

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.

Configure browser push notifications

Chrome (Android)
  1. Tap the lock icon next to the address bar.
  2. Tap Permissions → Notifications.
  3. Adjust your preference.
Chrome (Desktop)
  1. Click the padlock icon in the address bar.
  2. Select Site settings.
  3. Find Notifications and adjust your preference.