Hey there, i'm again with a assumption that could be wrong. (lol, probably i'm known as "wrong science theories guy").

It can be possible to plug some prosthesis and gene-changing to the neural cells degenerated by Parkinson disease? Like, make some steps to solve a Parkinson disease, same of a cancer treatment?

Well, that project I thinked is called THE GENIE: a process that changes the genes of specific areas to downcrease chances of Parkinson, by acting on their main areas. I will show it in some processes:

An apparel will check the neural structure of the black substance, and will detect areas and cells that could be probable to suffer with degeneration by Parkinson, then, the doctor will use a "transgenic techinique" to manipulate the flawed genes of the neural cells nucleus. First question is there, what's the relation of a Parkinson bad with flawed genes? Well, my assumption says that the degeneration is caused, along with the Lewy bodies, by genes flaws on the cell time of life, a accelerated time of life could make the cell die on a faster speed, considerating the average time of life. Adjusting some flawed genes SNCA, PARK2, PARK7, PINK1 and LRRK2 could treat the Parkinson in genetic therms.

Another thing to estabilish is the Lewy bodies, a grouping of alpha-sinuclein protein (a-sin) that happens when the a-sin have problems and can unfold itself and joint with other proteins, forming these aggregations that could obstruct and help in the kill of the neural cells, and, no, I'm not using the prion theory; We can find a key for the flawed proteins on the places that a-sin is produced on the brain, that today I will call "Carlsson terminal", in reference to Arvid Carlsson, discoverer of dopamine.

The Carlsson terminal in Parkinson's could have structural problems on their genes, so, what if we uses THE GENIE to unlock the flawed ones and fix it? Flaws on SNCA gene could make the protein more elastic and more flexible, making an link to unfolding and joint on Lewy's, also, passing these themes of genes, we also can use, maybe an chemical treatment, to reduce the reactive oxygen species, making the chance of unfolding even more difficult, like putting weights on each border of a paper to make impossible to the paper get blown by the wind and flews away.

That could be wrong, but, with the transgenic advances and the nanotechnology ghost on everything, that could be possible, early or late, and I will gain an Nobel Prize post-mortem (LOL again).

I hope that you liked it, and have a nice flight.

Edited May 24May 24 by Heitor Silva

There are gene therapy approaches for Parkinson’s

https://www.apdaparkinson.org/article/gene-therapy-for-parkinsons-disease/

I defer to experts in deciding what the most promising avenues are to pursue

At this time my assumption is correct (I'm feeling like Nostradamus, but by discovering that my assumption was based on a already exist thing lol)

Edited May 24May 24 by Heitor Silva

It should be noted that there are only few mutations ("defective or flawed is a bit of a misnomer, most of the time from a biological perspective, though I am aware that some folks in the medical profession use that in communications). There are only few genes known to be associate with Parkinson's, which is not the same as causing it. One example is a mutation GBA1 which increases risk of inflammation and negatively affects clinical progression of the disease (i.e., there are folks who have the mutation and are fine, but once it Parkinson's is diagnosed, the clinical outcome is worse in patients with this mutation.

The hope is replacing the mutation could stop or stop progression and has been in clinical trials. However, at least one was terminated and at least as far as I am aware the rest are still ongoing.

Other gene therapies target some of symptoms and try to increase dopamin levels genetically. One of these approaches has been in trial maybe a decade ago at least passing Phase II and I am aware that a 5-yr follow up suggesting that motor improvement was still observed in most patients in that time period (which was a major concern for this particular route). However, the improvements were generally moderate.

I am sure there is more around, but