Hi all,
the idea of a synthesis post seems very good to me. I will hopefully contribute with another example later and just wanted to make a few suggestions:
The catalysis of that [4+3]Cycloaddition with a Rh(II) precatalyst (not pseudo-[4+3]? Is the Cyclopropane-Intermediate 4 really an intermediate? Could it be isolated?) seems a powerful synthetic tool for the stereoselective preparation of seven-membered rings, but how can I know for sure whether it is, when no yield or ee/ratio of diastereomers is given? (An ee of 90 % is good, thoug. What was the conversion?) I would be very grateful if that could be implemented in the next posts, as well as reagents and reaction conditions. Otherwise it makes no sense to discuss about alternatives or optimization of certain steps of a synthesis.
Another nice thing would be to post a retrosynthesis first and discuss the various reasonable and then selected disconnetions and respective transforms. Especially with more complex targets, this is perhaps the best approach to a fruitful discussion...
I will be happy to contribute with a synthesis later.
