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Posts posted by tkadm30

  1. You are repeating words but do you know what they mean? What, for example is an exosome and what is the relationship specifically with RNAi? Have you checked the difference between silencing and knockout? And do you then understand why these are two unrelated mechanisms?

    I understand that RNAi and CRISPR are systems for genome editing. Gene knockout occurs at the DNA level, while gene silencing is produced from enzymatic reactions.

  2. That doesn't make sense. CRISPR is not a RNA delivey tool (and hence does not apply to OP at all). The linked paper actually explains the differences.


    CRISPR/Cas9 is a RNA-guided endonuclease system. The advantage of using CRISPR over RNAi (exosomes) is that CRISPR can "turn off genes at the DNA level, creating a knockout." http://scopeblog.stanford.edu/2016/05/10/crispr-or-rnai-which-gene-switch-is-better/

  3. Dopamine/CB1 receptor cross-talk = fine-tuning of dopamine D2 receptors = enhances cAMP activity


    "Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?"




    cAMP is a promoter of calcium-dependent synaptic exocytosis.

  4. Hi,


    Brain-to-brain connectivity is evidence of non-local biological entanglement.


    See: http://www.sciencedirect.com/science/article/pii/S1877042815018406


    I'm looking for positive scientific inputs about the quantum-like nature (entanglement, coherence) of brain-to-brain connectivity. :)


    Also, the biological utilization of quantum nonlocality by brain (neuronal) processes is highly interesting.




    Thanks in advance,



  5. How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?


    Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

    We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.


    I'm thinking of dopaminergic "fine-tuning" as a dopamine-mediated enhancement of synchrony in the gamma range. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697121/

  6. The effects of cannabinoids on neural communication (synaptic plasticity) are poorly understood. Does cannabinoids (THC) fine-tune or disrupt neural oscillations in the gamma range? I find the hypothesis that THC may disrupt neural oscillations pretty much obsolete as there no evidences of disruption of synchrony by exogenous THC administration.

  7. My local observations are experimental evidences of synaptic hypercomputation: Endocannabinoid-mediated retrograde signaling is controlling synaptic connectivity

    and synaptogenesis. https://www.ncbi.nlm.nih.gov/pubmed/17525344


    Synaptogenesis is evidence of the quantum non-locality of interneural communication.


    By fine-tuning synaptogenesis, retrograde signaling modulate dopaminergic neurons and phase-transition driven exocytosis.


    The distinction I've tried to convey is that you are attempting to supplant facts with theories. What need have we for theories when we have incontrovertible facts based on unassailable evidence obtained through empirical research in neuroscience?

    The quantum nature of neuroscience cannot be ignored. In my opinion it is a mistake to not consider quantum-like presence in biological systems.

  9. I'm highly sure that quantum-like effects in biological systems are evidences of the quantum non-locality of consciousness.


    Consciousness is non-local because observation is depending on our perceptions and immaterial.


    Synaptic hypercomputation is evidence of macroscopic quantum coherence in brain activity.

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