tkadm30

Long-range synchronicity in the gamma band is evidence of quantum-like entanglement (neuronal phase coherence) in

interneuronal communication systems. http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003723

You are repeating words but do you know what they mean? What, for example is an exosome and what is the relationship specifically with RNAi? Have you checked the difference between silencing and knockout? And do you then understand why these are two unrelated mechanisms?

I understand that RNAi and CRISPR are systems for genome editing. Gene knockout occurs at the DNA level, while gene silencing is produced from enzymatic reactions.

That doesn't make sense. CRISPR is not a RNA delivey tool (and hence does not apply to OP at all). The linked paper actually explains the differences.

CRISPR/Cas9 is a RNA-guided endonuclease system. The advantage of using CRISPR over RNAi (exosomes) is that CRISPR can "turn off genes at the DNA level, creating a knockout." http://scopeblog.stanford.edu/2016/05/10/crispr-or-rnai-which-gene-switch-is-better/

Dopamine/CB1 receptor cross-talk = fine-tuning of dopamine D2 receptors = enhances cAMP activity

"Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?"

http://molpharm.aspetjournals.org/content/67/5/1697.short

cAMP is a promoter of calcium-dependent synaptic exocytosis.

It is foolish to ignore the macroscopic quantum-like nature of biological systems.

Hi,

Brain-to-brain connectivity is evidence of non-local biological entanglement.

See: http://www.sciencedirect.com/science/article/pii/S1877042815018406

I'm looking for positive scientific inputs about the quantum-like nature (entanglement, coherence) of brain-to-brain connectivity.

Also, the biological utilization of quantum nonlocality by brain (neuronal) processes is highly interesting.

Thanks in advance,

tkadm30

Here's a famous quote from Max Planck:

 

"I regard consciousness as fundamental. I regard matter as derivative from consciousness. We cannot get behind consciousness. Everything that we talk about, everything that we regard as existing, postulates consciousness."

The binding problem of consciousness is certainly a major issue in implementing brain-computer interfaces. Then you need to understand the quantum effects (entanglement, coherence) driving interneuronal communication systems.

CRISPR is rapidly becoming a standard research tool in siRNA delivery.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813155/

Can THC, as a CB1 partial agonist, modulate dopamine cross-talk and synchrony in the gamma range?

How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?

 

Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.

I'm thinking of dopaminergic "fine-tuning" as a dopamine-mediated enhancement of synchrony in the gamma range. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697121/

The effects of cannabinoids on neural communication (synaptic plasticity) are poorly understood. Does cannabinoids (THC) fine-tune or disrupt neural oscillations in the gamma range? I find the hypothesis that THC may disrupt neural oscillations pretty much obsolete as there no evidences of disruption of synchrony by exogenous THC administration.

1. Local communication is described here: https://en.wikipedia.org/wiki/Communication

2. Local (quantum) observation is a computation of a conscious experience

3. Through language semantics and neural representations

4. Internet connection...

5. Quantum entanglement of neural communication is evidence of synaptic hypercomputation

 

 

What are "local observations"?

How are you measuring "quantum connectivity"?

What experimental setup do you use, what results have you obtained?

https://en.wikipedia.org/wiki/Observer_(quantum_physics)

You can measure quantum connectivity through local communication.

My local observations of brain-to-brain quantum connectivity in neural communication is experimental evidence of synaptic hypercomputation. In a quantum system, a local observation is functionally different than a non-local (remote) representation of a abstract concept.

Selective anandamide binding may activate dopaminergic neurotransmission.

My local observations are experimental evidences of synaptic hypercomputation: Endocannabinoid-mediated retrograde signaling is controlling synaptic connectivity

and synaptogenesis. https://www.ncbi.nlm.nih.gov/pubmed/17525344

Synaptogenesis is evidence of the quantum non-locality of interneural communication.

By fine-tuning synaptogenesis, retrograde signaling modulate dopaminergic neurons and phase-transition driven exocytosis.

Imagination and creativity are qualities of the mind to fabricate reality; Schizophrenia is a fabrication of psychiatry to

control and repress creative thinking with psychological oppression.

i take monthly injections of abilify (maintena). it does virtually nothing except it increased my blood pressure and made me less sleepy.

Since when veterans of war return home with a schizophrenia-like disorder/hallucinations ?

Auditory hallucinations are not a component of PTSD...

"Schizophrenia is a moral verdict masquerading as a medical diagnosis."

http://www.herinst.org/gosden/rgosdenPhD/chapter8.pdf

 

I think you confuse creativity and imagination with reality. (Which is likely a symptom of schizophrenia.)

I think you have no evidences for such claim.

Why don't you show me a paper about the auditory effect in schizophrenia...

 

 

An unproven hypothesis is not evidence.

It is at least a functional postulate to confirm the presence of quantum vibrations in microtubules.

 

The distinction I've tried to convey is that you are attempting to supplant facts with theories. What need have we for theories when we have incontrovertible facts based on unassailable evidence obtained through empirical research in neuroscience?

The quantum nature of neuroscience cannot be ignored. In my opinion it is a mistake to not consider quantum-like presence in biological systems.

 

 

That's not enough. It's not anything, really. What evidence do you have?

http://www.sciencedirect.com/science/article/pii/S1571064513001188

The Orch OR theory is evidence of the quantum non-locality of interneural communications. (biological entanglement/hypercomputation)

I'm highly sure that quantum-like effects in biological systems are evidences of the quantum non-locality of consciousness.

Consciousness is non-local because observation is depending on our perceptions and immaterial.

Synaptic hypercomputation is evidence of macroscopic quantum coherence in brain activity.