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Chloroform?


H2SO4

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I know alot of compounds can make you pass out fairley quick, bt whats the most popular one. I got in this big argument on another forum thats wasnt even science related. He said it was chloroform. what is the molecular formual. What is it? I said it was ethyle that was most popularly used for this application. I dont know what either of these are, but i got in a argument and i knew this guy had no idea whats going on anyway.

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chloroform isnt used so much anymore because it can kill. it is produced by a haloform reaction, a form of nucleophilic substitution:

R-COCH3+3MOCl-->R-COCCl3+3MOH

R-COCCl3+3MOH-->R-COO-+M++CHCl3

 

also,

 

R-COCH3+3X2+4MOH-->R-COO-+M++CHX3+3X-+3H2O

 

i've been studying for my orgo I class :D

 

btw, this reminds me. for home production of chloroform with minimal other waste products:

since you need a methyl ketone, why not use acetone? it is a doubly methylated ketone:

H3CCOCH3

thus, if one were to use 6MOCl, would one not achieve twice the chloroform and no R product?

H3CCOCH3+6NaOCl-->Cl3CCOCCl3+6NaOH-->2Na+ -OOCOO- +2CHCl3

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I'd like to think i understood all of that but i will admit that i had a problem with some of the notation. But most of all what the hell is 'OOCOO-' does that even exist? I would realy like to get this do you think you could explain it a bit easyer, like what are all the letter notations is M methyl, R alkyl group maybe im just guessing. Thanks.

 

~Scott

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Ok dibasic is when two hydrogens are removed right now that makes sense. However OCOO- is still wrong. Carbonic acid H2CO3 will leave OCOO2- bonding with the metal sodium in this case to form Na2CO3 Not NaCO3 which OCOO- suggests.

 

~Scott

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Guest atarax

Chloroform isn't really that dangerous in the short term, but it causes cancer. I think most places use a combination of enflurane and propofol these days. (enflurane is an inhalation anaesthetic, and propofol is IV)

 

enflurane is 2-Chloro-1,12-trifluoroethyl difluoromethyl ether.

propofol is 2,6-diisopropylphenol.

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Missed a comma I guess, probably..

 

2-chloro-1,1,2-trifluoroethyl difluoromethyl ether

 

This site gives the same structure though. Chinese whispers?

http://environmentalchemistry.com/yogi/chemicals/cn/Enflurane.html

 

I looked it up in JACS and they give it as:

2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane, CHFCl-CF2-O-CHF2

 

Edit: Reference is Pfeiffer A, Mack H-G, Oberhammer H. Enflurane: Structure and Conformational Properties. J. Am. Chem. Soc. 1998, 120, 6384-6388

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organic is all about the carbon. there is an infinite number of organic molecules. there are many breakthroughs in organic involving biochem and such that can explain why organisms work the way they do.

 

with organic, you see things in such a different light. everything is subtle. organic requires patience and is really an art. you need to be very precise and accurate in a lab situation. the way chemicals work in organic is so much more interesting than the way they interact in inorganic chem. hard to explain. there is so much more to do with organic and a million ways to do it. plus it's the most difficult science.

 

i dunno, it's hard to explain my fascination with orgo

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The whole reason why I think it's scary is because the materials needed to make it are VERY readily available and it's so easy to do. There's also a lot of idiots out there who can severely hurt themselves, others, and the environment by trying to make the stuff. :(

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  • 3 years later...

Don't forget that Chloroform has special storing procedures. Like H2O2 one is supposed to store it in a brown bottle away from light and too much heat/UV radiation.

 

A natural decomposition product is the deadly nerve gas phosgene :) Or so I've read anyways...it starts decomposing after about two weeks.

 

Also it is metabolized in the body to phosgene which is bad for teh liver apparently.

 

wouldn't want to e'er get a breathful of that particular gas :P

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