taxstin Posted November 3, 2011 Share Posted November 3, 2011 At the end of step 10 of Glycolysis (phosphoenolpyruvate to pyruvate) you generate 1 ATP. However from what I've been told there is actually enough energy to generate 2 ATP there but it doesn't happen for whatever reason. So my question is what can you do to drive the reaction to produce that 2nd ATP? I heard something about using inorganic phosphate to drive the reaction but I don't know the details. Link to comment Share on other sites More sharing options...
Papaver Posted November 4, 2011 Share Posted November 4, 2011 Only one ATP is produced because phosphoenolpyruvate has one phospho group which can be transfered producing ATP. In Glycolysis you got at that step 2 ATP because two phosphoenolpyruvate are converted to pyruvate and ATP. I don't know if it it possible to drive the reaction to produce more ATP. Maybe in vitro but I doubt that is the way it works in cells. Especially because there is a negative regulation of pyruvate kinase by ATP. Link to comment Share on other sites More sharing options...
CharonY Posted November 4, 2011 Share Posted November 4, 2011 I think the total free energy of the hydrolysis of PEP is roughly twice that of ATP. That allows the transfer of P from PEP to ADP. However, PEP has only one phosphate to offer. Where should the second come from? Link to comment Share on other sites More sharing options...
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