picking a cell line

[beachbum]

when researchers test different symptoms or processes in the human body they use different cells for experimentation. how do you know how to pick the right cell line?

[ecoli]

It's pretty obvious it many cases. For example, I'm doing work on uropathogenic E. coli, so I would obviously choose tissue cultures from the bladder or kidneys.

[Bluenoise]

Yeah you basically pick the tissue that will show the most significant effect. Like if it's a disease you pick the affected tissue, the same for toxicoloy etc. There isn't really much of a question of picking an appropriate tissue in most cases. And if there is it's usually pretty limited.