When the stomach gets the food and start to digest it satiety hormones are been secreted thus telling us to stop eating correct? food stays in the stomach itself for about 3 to 4 hours which is the average time of satiety. when the food leaves the stomach it becomes chyme and goes to the small intestine . when the stomach is empty-meanning there is no food there,ghrelin is been produced ,telling us to start eating again. What i dont get is,the food leaves as chyme to the small intestine and emptying the stomach,but when that chyme goes into the small intestine hormones of satiety are been secreted as well there,telling us not to eat,but that contradicts the fact that when that chyme leaves the stomach we begin to feel hungry again ,so what am i missing? thank you

Perhaps the hormone is denatured either in the stomach or the small intestine.

Yes, like StringJunky said, the hormone may be denatured, or the satiety hormone that is released when the chyme enters the small intestine may only be a small amount.

 

Yes, the hormone is released, but it may be an insufficient amount, or possibly some kind of delay is involved in which the satiety is only short lived.