Custom layout CVs (resumes that is) seem to be a lot more common in creative sectors. Graphic designers, for instance, might decide to demonstrate their skills this way. Generally though, I think it's about balancing the need to stand out amongst the crowd with clearly displaying your credentials. Recruiters and hiring managers have to shift through a mountain of CVs, so it's a double-edged sword. On the one hand, a custom layout may be more eye-catching, but on the other it might end up frustrating them because they can't find what they're looking for. As long as you clearly lay out your experience and/or education (depending on how much experience you have), skills, and contact details, you should be ok. That said, if in doubt, work from a template!