PhilGeis
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Posts posted by PhilGeis
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Wish folks would offer some citations for their assertions
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Above tells you nothing of mode of action - merely its expression.
Curious - is this in defense of an advanced degree?
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Continuation of current discussion
Info largely based largely based personnel communications - leaked info. Release/declassifying of investigation will help understand issue and considerations of FBI and DOE - if it is released.
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Wuhan lab scientists were the first to contract COVID-19: report
https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijs.0.65021-0
vs. 2021 claim it was a wet market vendor and a WHO claim it was an accountant
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Think a bit oversold at this point. "International group" may not be so correct. French lab examination of sequences posted to a public genomic database by Chinese researchers and subsequently removed.
Seems others could reproduce findings but see nothing in literature yet.
WHO asked for the data, not aware it's been released/
But there is relevant previous (to above) discussion relevant to racoon dog association.
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China offers a new theory and vector for wet market source - "racoon dog'
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Fauci said Saturday that a coronavirus lab leak could still be considered a "natural occurrence" if the definition of lab leak meant that someone was infected in the wild and went "into a lab," was studied in a lab, and then "came out of the lab."
and
"The other possibility is someone takes a virus from the environment that doesn't actually spread very well in humans, and manipulates it a bit, and accidentally it escapes or accidentally infects someone and then you get an outbreak,
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On 3/4/2023 at 2:36 PM, CharonY said:
Of the virus. E.g. via accidental infection during work.
To CharonY's point, to the possibility of lab worker infection , esp. in context of alleged inadequate controls
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declassification will help us understand FBI/DoE thinking
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2 hours ago, John Cuthber said:
Which would be the appropriate control measures for a bat virus, and vastly more than those in a wet market.
So what? Not aware the virus was not found in the wet market.
Again FBI and DoE both cite the lab as the probably source.
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Both FBI and DoE reviews offered as probable the "lab leak" source based on their review.
Please also recall Wuhan work was reportedly conducted in a BSL-2 lab - the limited contamination control standards used typically in micro 101 teaching labs.
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Microwave treatment can indeed kill bacteria tho' a brief exposure such as heating yogurt prob will not eliminate all viability. Be aware - microbial populations in commercial yogurts are unstable and decrease of viable counts are common to the point that claimed benefits are more hype than substance.
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3 hours ago, PhilGeis said:
Review - notes value in combined therapy - bacteriophage and antibiotic. Suggest folks remember their virology lab with bacteriophages and E. coli from sewage - the ease with which resistance was demonstrated
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5 hours ago, StringJunky said:
WALOB, Phil. First thing I do is check out the authors... fresh out of the Republican echo chamber. WTH do economists know about epidemiology?
I can't parse how you think these authors are worthy of your attention, as a microbiologist yourself.
Please - let's not invest political bias in the discussion. Suggest you drop the ad hominem and read the assessments.
Thanks for the critique editorial.. Afraid most of it is similarly ad hominem.
What metrics would you think best to estimate impact of lockdowns? the articles included deaths per capita by state, in school days lost and economic impact. Flatten the curve 'til vaccine was the original purpose but infection rates are tough to see valid as reporting enjoyed no protocol and most likely went unreported.
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https://www.nber.org/papers/w29928
"While this meta-analysis concludes that lockdowns have had little to no public health effects, they have imposed enormous economic and social costs where they have been adopted. In consequence, lockdown policies are ill-founded and should be rejected as a pandemic policy instrument."
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On 4/1/2022 at 6:26 PM, BabcockHall said:
Is there any point in repeating a successful disk diffusion assay at lower starting concentration of substance? Or would it make more sense to move to some form of minimum inhibitory concentration assays?
No. Just run an MIC.
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20 hours ago, MigL said:
Even vaccines work that way.
They provide a blueprint ( or a map, if you like the GPS guided bomb analogy ), so that you body's own defenses can target the specific intrusive virus, with antibodies.Good point. And the mRNA-based vaccines ever more of a focused magic bullet.
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Perhaps antibody therapy for relevant cancers https://pubmed.ncbi.nlm.nih.gov/22437872/ and https://www.criver.com/eureka/magic-bullets-the-next-evolution-in-targeted-cancer-therapy
and the term has meaning in the history of micrpbiology https://www.smithsonianmag.com/smart-news/syphilis-cure-magic-bullet-180964644/
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On 2/18/2022 at 6:48 AM, exchemist said:
I'm not what sources you are relying on but in the UK here seems to be a fair amount of evidence that the vaccines work pretty well at reducing the severity of infection with the Omicron variant. There is a paper here on it: https://www.gov.uk/guidance/monitoring-reports-of-the-effectiveness-of-covid-19-vaccination
My comments addressed omicron strain.
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12 hours ago, CharonY said:
Which means they allow vaccinated individuals to mount an effective immune response, which in turn is the function of a vaccine...?
The stated purpose and function of this vaccine and its controversial mandates is to address the pandemic.
No - it does no mean effective immunity. There is an association with reduced morbidity and mortality. Coincidence is not cause and assuming "immunity" is not justified. Numbers are not normalized
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6 hours ago, John Cuthber said:
Two years from sequencing and a year after launch, the vaccine is still doing a fairly good job.
The vaccine vs omicron is apparently useless as a "vaccine". Reportedly is associated with better outcome in morbidity and mortality
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Covid has a high mutation rate - up to 10X greater than the already high rate of RNA viruses in general.
Mutation shows the limitation of current mRNA based vaccine technology - so narrowly focused, variants move out of efficacy range. Tho' justified in part on the rapidity of development and warranted as you say by variant generation, it still takes too long to develop and administer. Appears there is no attempt to develop.
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Germs on laptop keyboard
in Microbiology and Immunology
Posted
Please read the citations offered. The article reported the flora recovered from keyboards.
Potential pathogens cultured from more than 50% of the computers included coagulase-negative staphylococci (100% of keyboards), diphtheroids (80%), Micrococcus species (72%), and Bacillus species (64%). Other pathogens cultured included ORSA (4% of keyboards), OSSA (4%), vancomycin-susceptible Enterococcus species (12%), and nonfermentative gram-negative rods (36%)