karlerikt Posted May 23, 2015 Share Posted May 23, 2015 My question:When Ibuprofen and Aspirin are NSAIDs and work to inhibit/change the cyclo-oxygenase pathway (COX), then how come they are used to treat SIMPLE HEADACHES? A normal headache is not an inflammation in the brain - a brain inflammation will be something much more serious. Can it be that Ibuprofen is used as a placebo drug against mild headaches all these years? Thank youMed student year II Link to comment Share on other sites More sharing options...
StringJunky Posted May 23, 2015 Share Posted May 23, 2015 ...Can it be that Ibuprofen is used as a placebo drug against mild headaches all these years? Thank you Med student year II I think so. I can. take a headache tablet (any) and within 10 minutes it is subsiding. It is not feasible that the active ingredients have arrived at the necessary areas, in sufficient quantity to start working. Link to comment Share on other sites More sharing options...
Prometheus Posted May 23, 2015 Share Posted May 23, 2015 My understanding is that inhibiting the COX pathway also inhibits prostaglandin production thus NSAIDs have an analgesic and an anti-inflammatory effect. 1 Link to comment Share on other sites More sharing options...
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