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What does Omega 3 (DHA) really do?

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An Na-channel is a membrane protein that conducts Na-ions  through a cell's plasma membrane.  Depending on the trigger that opens the Na-channel, it's called voltage gated (when the channel opens because of a voltage-change) or ligand gated (when the binding of a ligand opens the channel). The Na-channel mediates fast depolarization and conduct electrical impulses throughout nerve, muscle and heart, thereby enabling co-ordination of higher processes ranging from locomotion to cognition.

Docosahexaenoic acid (Omega-3)(DHA) suppresses  the activity of Na-channels. That's the main reason why Omega 3 lowers the heart rate and causes many of the beneficial effects.. Clinical and experimental data indicate that changes in the expression of voltage-gated sodium channels play a key role in the pathogenesis of neuropathic pain and that drugs that block these channels are potentially therapeutic. Clinical and experimental data also suggest that changes in voltage-gated sodium channels may play a role in inflammatory pain, and here too sodium-channel blockers may have therapeutic potential.

In another paper they compared the working of ibuprofen with omega-3 EFAs on arthritic pain. They found an equivalent effect in reducing arthritic pain. So it seems that Omega 3 might be a good/safe alternative for NSAIDs.

If you have some interesting information concerning this subject you can back up....




Edited by Itoero

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