Itoero Posted August 12, 2017 Share Posted August 12, 2017 (edited) An Na-channel is a membrane protein that conducts Na-ions through a cell's plasma membrane. Depending on the trigger that opens the Na-channel, it's called voltage gated (when the channel opens because of a voltage-change) or ligand gated (when the binding of a ligand opens the channel). The Na-channel mediates fast depolarization and conduct electrical impulses throughout nerve, muscle and heart, thereby enabling co-ordination of higher processes ranging from locomotion to cognition. Docosahexaenoic acid (Omega-3)(DHA) suppresses the activity of Na-channels. That's the main reason why Omega 3 lowers the heart rate and causes many of the beneficial effects.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483717/ http://www.sciencedirect.com/science/article/pii/S1357272506002159?via%3Dihub Clinical and experimental data indicate that changes in the expression of voltage-gated sodium channels play a key role in the pathogenesis of neuropathic pain and that drugs that block these channels are potentially therapeutic. Clinical and experimental data also suggest that changes in voltage-gated sodium channels may play a role in inflammatory pain, and here too sodium-channel blockers may have therapeutic potential. http://www.jpain.org/article/S1526-5900(06)00508-6/fulltext In another paper they compared the working of ibuprofen with omega-3 EFAs on arthritic pain. They found an equivalent effect in reducing arthritic pain. So it seems that Omega 3 might be a good/safe alternative for NSAIDs.https://www.ncbi.nlm.nih.gov/pubmed/16531187 If you have some interesting information concerning this subject you can back up.... Edited August 12, 2017 by Itoero Link to comment Share on other sites More sharing options...
IanH Posted April 19, 2018 Share Posted April 19, 2018 I have been keen on DHA for cvd however a recent meta analysis found otherwise: \ Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks - Meta-analysis of 10 Trials Involving 77 917 Individuals JAMA Cardiol. Published online January 31, 2018. doi:10.1001/jamacardio.2017.5205 The studies used dosages from 226mg/d to 1800mg/d. The dosage is contentious. I recommend 3 grams twice daily for neuropathic pain (incl fibromyalgia) and get quite good results but I also recommend it combined with vitamin D 5000iu/d Whats your thoughts on dosage? Link to comment Share on other sites More sharing options...
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