could sentience, given enough knowledge of the "why anything" question, take that knowledge and affix a meaning to the word "spiritual" that would infer a way of changing (upgrade) the spiritual environment of the observer, given that the knowledge acquired allowed a spiritual realm to have a plausible reason to exist? If the start of the universe was 13.7b years ago, then everything from that microsecond after the big bang is second hand news. So, an upgraded religion would take the central idea of that there is a physics, or proto-physics of a prior era, and that it will eventually be ascertained.

If you're asking "Can the prefrontal cortex of the human mind conceive of imaginary concepts", the answer is yes.