linenup Posted January 15, 2012 Share Posted January 15, 2012 Hi: Thank you for answering my question. My question is concerning the efflux pump and MDR 1/ I was under the belief that efflux pumps were specific to biofilm formation, if the pathogen is not a biofilm related organism, can efflux pumps still exist? 2/ Are efflux pumps the main obstacle in multi drug resistance? 3/ Does anyone have any resources on natural or pharma efflux pump disablers? Thanks for your insight! Link to comment Share on other sites More sharing options...
CharonY Posted January 16, 2012 Share Posted January 16, 2012 Based on your question I assume that you mean bacterial efflux pumps. 1) No, they are not specific to biofilms. I assume that you learned about them in this particular context, but there are a large variety of efflux pumps. Most are involved in detoxification, though. 2) Not necessarily, there are other mechanisms. However, they are a very common theme. 3) It is not really my field, but there is quite a body of literature regarding inhibitors out there. For instance: J. Antimicrob. Chemother. (2007)59 (6): 1247-1260. Link to comment Share on other sites More sharing options...
linenup Posted January 17, 2012 Author Share Posted January 17, 2012 CharonY: Thank you so much for your insight! Link to comment Share on other sites More sharing options...
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