Hi: Thank you for answering my question. My question is concerning the efflux pump and MDR

 

 

 

 

1/ I was under the belief that efflux pumps were specific to biofilm formation, if the pathogen is not a biofilm related organism, can efflux pumps still exist?

 

 

 

 

2/ Are efflux pumps the main obstacle in multi drug resistance?

 

 

 

 

3/ Does anyone have any resources on natural or pharma efflux pump disablers?

 

 

 

 

Thanks for your insight!

Based on your question I assume that you mean bacterial efflux pumps.

 

1) No, they are not specific to biofilms. I assume that you learned about them in this particular context, but there are a large variety of efflux pumps. Most are involved in detoxification, though.

 

2) Not necessarily, there are other mechanisms. However, they are a very common theme.

 

3) It is not really my field, but there is quite a body of literature regarding inhibitors out there. For instance: J. Antimicrob. Chemother. (2007)59 (6): 1247-1260.

CharonY: Thank you so much for your insight!