I have very little experience in the field of genetics and would really appreciate your help. This is a highly-acclaimed paper, published in a very reputable journal; however, I have been told that there are some issues with it. Do you see what could be improved?

 

Thanks in advance!

Genetic variants in TPMT and COMT are associated with.pdf

Could you provide the reference and abstract, please?

Well, I was brave enough to open the pdf: http://www.nature.com/ng/journal/v41/n12/abs/ng.478.html

(you can/should probably delete the attachment now)

Edited January 6, 201115 yr by timo

Thanks Timo!

Just by a rough overview (really hardly reading), it appears to me that they did not consider multiple hypothesis testing. Or at least I could not see it. But on this level I cannot really say that it is really heavily flawed otherwise (but I would need to read in more detail to really be sure on anything).

Edited January 7, 201115 yr by CharonY