astcws Posted March 13, 2009 Share Posted March 13, 2009 I hope this question will not be too stupid. I am just very interesting in this subject and I am a beginner about biochemistry. Well. I found a new health supplement. It said people need to supplement extra 8 acid (Citrate, Isocitrate, Oxalosuccinate....) to make TCA cycle work perfect. What I know is TCA cycle produce these acid step by step and what will happen if add extra acid in it? I just think it may break down the TCA cycle....or I am wrong??? Link to comment Share on other sites More sharing options...
Kaeroll Posted March 13, 2009 Share Posted March 13, 2009 If won't break your Krebs cycle. It probably won't do anything. Bear in mind that the cycle is central to your survival, so is pretty damn efficient. Do you really think it needs supplements? Spend your money on something more useful and worthwhile (I recommend Rock Band... oh the fun...) Link to comment Share on other sites More sharing options...
astcws Posted March 13, 2009 Author Share Posted March 13, 2009 Hi, thanks, Kaeroll. One more question.... If I culture bacteria ,m...something like fermentation. Is it possible to increase the Aconitase??? Link to comment Share on other sites More sharing options...
Mr Skeptic Posted March 13, 2009 Share Posted March 13, 2009 Maybe it will slightly increase your metabolism. However, its not like your body can't make as much of these acids as it likes, so adding extra is probably not a good idea. Kind of like saying Hey, my body needs heat, I'm going to sit in the oven. In any case though, I doubt that there would be even close to enough of those acids in the supplement to make a difference, kind of like if you were taking water pills to hydrate yourself. Link to comment Share on other sites More sharing options...
CharonY Posted March 13, 2009 Share Posted March 13, 2009 You can overexpress genes in bacteria. However more often than not the results are not quite what you expect, because e.g. the increase of aconitase will result in further shifts in other enzymes. I am almost sure that it has been done already, but my bet is that there are pleiotropic effects. Link to comment Share on other sites More sharing options...
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