one model to induce sepsis is to treat macrophages with LPS from E-coli.

but we have many E-coli in our gut, why macrophages do not atack that E-coli and their LPS?

thanks for any reply

Let me hint at the answer. Where does sepsis occur? Accordingly where would macrophages attack E. colis?

you mean because of physical inability to interact in nature.....???

macrophages in blood and e-coli in gut....???

Yups. With exception of pathogenic invasive strains and maybe lesions in the gut epithelia.

thank's a lot