Aney Posted May 14, 2019 Share Posted May 14, 2019 Rgarding to Mannich reaction between amide and secondary amine, I had 2 spots one matching the reactant and another is different, I have 2 question 1. The technique can be followed ? Best technique to be used in synthesis of amide-amine Mannich ? 2. Can I separate these 2 spots ? Link to comment Share on other sites More sharing options...
hypervalent_iodine Posted May 15, 2019 Share Posted May 15, 2019 1. I am not sure what you want here. Have you encountered a problem in your synthesis? What procedure were you following? 2. I assume you mean spots on a TLC? If you can see two distinct spots you should be able to separate them, provided the difference in Rf is sufficient. Link to comment Share on other sites More sharing options...
Aney Posted May 15, 2019 Author Share Posted May 15, 2019 1. The procedure was refluxing the amide containing compound with paraformaldehyde until clear solution obtained, left for gentle stirring overnight, next day piperidine was added and again the mixture refluxed for several hours. Monitoring with TLC gave 2 spots as I said previously, attempts to make the product with single spot by adding more one of the reactant not successed 2. Yes, 2 distinct spots, do you think column chromatography is suitable ? Link to comment Share on other sites More sharing options...
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