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caters

LH inhibitor: Could it work?

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I was thinking about how the aliens in my generation ship story sterilize people that have a genetic disease but don't sterilize carriers. The complete spermicide for males makes perfect sense. But with females, it is more complicated. What complicates things with females? The menstrual cycle of course. What I am aiming for is a way to inhibit ovulation without also inhibiting menstruation. So I looked at graphs of the menstrual cycle and the hormones and thought that since LH is the 1 hormone that triggers ovulation in the first place, an LH inhibitor would stop ovulation from happening at LH levels that would normally trigger ovulation. And because it is not estrogen or progesterone(both of which stop periods and estrogen, if taken at the right time can actually act as a natural fertility drug, raising the chances of having twins and higher order multiples), those 2 hormones should still cycle as normal with dips corresponding to menstruation. So basically, ovulation has stopped but there is still a menstrual cycle.

 

But could a direct inhibitor of LH stop ovulation without stopping periods? Or would it have the same amenorrhea effects as estrogen and progesterone do along with the direct effect of anovulation?

Edited by caters

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Why choose to inhibit LH?  There is an alternative. The body can be flooded by an LH analogue that binds to LH receptors and therefore causes downregulation of LH.  It is an easier option than directly targetting LH or GnRH. This would stop ovulation but allow the rest of the cycle to take place IMO.  The truth is that I don't know and am making an educated hypothesis.

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