sullivjo Posted May 28, 2017 Share Posted May 28, 2017 The packing of drugs into mitochondria for administration and delivery to the site of action in vivo could be efficient as it could avoid immune response being an endogenous nanoparticle and be membrane permeable with improved drug lifetime. Attachment of mAbs to the outer membrane may direct it to the desired cells/site of action. This method may be also possible for gene therapy. Is this method feasible or at least a worthwhile topic of research? Link to comment Share on other sites More sharing options...
Endy0816 Posted May 28, 2017 Share Posted May 28, 2017 Did you mean exsomes(which they are looking into for this purpose)? https://www.ncbi.nlm.nih.gov/pubmed/22776312 Nanoparticles are between 1-100 nm. Mitochondria fall outside that range. Link to comment Share on other sites More sharing options...
sullivjo Posted May 29, 2017 Author Share Posted May 29, 2017 Thanks for the correction, for some reason I associated mitochondria with nanoparticles. I was simply suggesting mitochondria as an alternative to exosomes. Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now