Hi everyone. I have a problem and question for you. I'm working on some organic synthesis and end of the synthesis, I have undesired product which is 1,3-dichloropropanol. How can I remove this chemical. I have tried evaporation but this is not feasible because this need very much energy. If you help me, I will be pleasure

Could you possibly give some more detail on the desired product? Why is the energy requirement for evaporation too high?

Desired product is chlorohydroxypropyl ammoniumchloride which is made by reaction epichlorohydrin and trimethylamine hydrochloride. 1,3-DCP is undesired byproduct. And to remove is dificult because its boiling point is 174C. I tried some resins to remove but it didnt work.

Desired product is chlorohydroxypropyl ammoniumchloride which is made by reaction epichlorohydrin and trimethylamine hydrochloride. 1,3-DCP is undesired byproduct. And to remove is dificult because its boiling point is 174C. I tried some resins to remove but it didnt work.

Do you have access to a controlled vacuum? You could vacuum distill the DCP off with mild heating. Strange that ion exchange resins didn't work though. What were you using?

Yes we tried vacumm distilation, it works, but it spends much time. And we tried resin, dcp decreased to 2000ppm from 10000ppm. But there is a problem that active matter decrease to.