Alfred001

I think that was just one of the speculated hypotheses, I don't think the mechanism of action was known, but now Follica says microneedling induces the generation of new hair follicles through stem cell division. My concerns are the ones outlined in this video and I'm wondering if anyone is knowledgeable enough on this topic to tell me whether this is a realistic concern, given stem cell division in generation of new hair follicles

I learned about it from a company called Follica which is developing a hair loss treatment. Here's an article summarizing the results they announced. I don't know whether there's independent research that found hair follicle neogenesis, but there is research showing microneedling induces hair growth in balding men.

If you're unfamiliar with it, microneedling is a proceedure used for skin rejuvenation (including removing scars) and hair loss. A device is used to create many many tiny needle puncture wounds on the skin or the scalp. It's something htat is becoming increasingly popular, but it seems to me, with my limited knowledge, that there might be some cancer concerns here through two distinct mechanisms: 1) What is described here starting with the header "Dermarolling May Trigger Tumor Formation" 2) generation of new hair follicles through stem cells When used on the scalp, microneedling induces the creation of new hair follicles through stem cell division. From what I understand, cancer can happen when cells start dividing and don't stop when they are supposed to. The idea behind microneedling is to generate an immense number of stab wounds. For example, there are dermapens that stab with 35 needles simultaneously and people are supposed to move these around their head and cover the whole scalp multiple times, so the numbers are extraordinarily large. Seems to me with so much stem cell division, isn't there a risk of something going south? Is that a plausible scenario?

#1 If you have a sphere with an axis through it around which it rotates, is the number of possible axis it can have finite or infinite? #2 This is maybe the same question in a different way, but what's got me confused is this: Is the number of possible positions (for a point) on a finite line finite or infinite? Because the way I'm thinking about it, you can take a point and put it a certain distance from one end of the line and then you half the distance and get another position and you half it again and again... you get the idea, you can half it an infinite number of times, which seems to give an infinite number of positions on a finite line. So how can there be an infinite number of positions on a finite line?

I was reading this Quanta article https://www.quantamagazine.org/how-nature-defies-math-in-keeping-ecosystems-stable-20180926/ And the following quote appears in it: “People have made a lot of progress in genetics by studying model organisms,” Can someone give me an example of progress being made in genetics by studying model organisms or explain in principle how progress is made by studying model organisms?

I will be using a 1.5mm dermaroller on my scalp as part of a hairloss treatment and I'm wondering: #1 What can I sterilize the needles with and how long do I need to soak them? #2 What should I use to disinfect the skin I will be needling?

I'm not just looking at forums, but studies, including things that are in trials. Furthermore, even the stuff that is FDA approved works wonders for people and does squat for others, so it's not like the only possible scenario is you hit on a cure that works 100% for 100% of people and you're a billionaire. There are many different remedies that have small effects, many of them are natural and available for cheap in supermarkets so you can't make a killing off them. The studies I read and that got results aimed at killing bacteria. It's possible that their anti-bacterial also had anti-fungal effects, but fungi were never mentioned. You seem to be knowledgeable on this topic. Are you a dermatologist or have you studied this? ??? I've already mentioned two natural substances that have those properties

There are only 3 FDA approved treatments for hair loss, so you know what the dr is gonna give you. There are big forums and communities around hair loss, as you can imagine, and people do a lot of research so they know what's out there and how effective it is. In most cases, if you want to have significant success fighting hair loss, you have to go beyond what the typical dr will give you and look into emerging treatments or stuff that's appeared in the literature more recently and is likely not known to your average dermatologist. No, the exact cause of male pattern baldness is not exactly known and it is believed that it might be multifactorial. Microorganisms and inflammation have been implicated and there's one study I read (albeit with a small sample size) where they were able to outperform one of the typical treatments (Minoxidil) by combining it with tea tree oil and an anti-inflammatory. The presumed mechanism was that TTO was killing whatever microbes were there and the anti-inflammatory was reducing the inflammation and that yielded results. Yep, Manuka is a good one and I've thought about it, but it's a little on the expensive side and possibly too expensive for what is, really, a speculative treatment that could go nowhere. Also, I should point out, I need something that has bactericidal, not just inhibitory effects. It needs to kill whatever is already there. But, I THINK, Manuka has that ability for a wide range of microbes. Yeah, a lot of essential oils are potent antibiotics, but, from what I've read, they're very dangerous and I'm a little afraid of using them. If anyone knows any safe one (I doubt such exsists) or can assuage my fears and knows for sure how they can be used safely topically on the scalp, you could help me out a lot. I'm open to this and maybe that would be the best option. It would have to be: - fairly cheap - come in some form that can be applied topically to the scalp (I'm not sure, but I believe that any substance applied to the scalp will find it's way to the blood through the hair follicles) - be free of any serious side effects If anyone can suggest something that meets those criteria, I'd be very grateful to you. Yeah, you're right about that, I just kind of assume that something natural is more likely to be something cheap and possibly have fewer side effect or toxicity concerns, but quite possibly none of that is true. So, just to update you all on where I stand with this, because my thinking has evolved since the original post. The point of this is that microbes and inflammation have been implicated as factors in hair loss and I'm looking for a way to fight them. I read a study where they achieved some good results through doing that, but I'm inclined to not use what they used in the study (tea tree oil and diclofenac), because of toxicity concerns and because I assume (haven't looked into it yet) that diclofenac is pricey. So, if anyone can recommend an anti-inflammatory and an anti-microbial that kills a broad spectrum of microbes (kills, not just inhibits), you could save me a lot of time, stress and aggravation. Both would have to be: - affordable - free of serious side effects - in a form that can be applied topically - safe for application to scalp (I'm not sure, but I believe anything applied to the scalp gets into the blood through the hair follicles) I looked into essential oils for anti-microbial, but got turned off them because of safety concerns. Lots of people ending up in comas and dead cats from essential oils. They can probably be used safely if properly diluted, but it would take a lot of research time (which I don't have) and I'm hesitant to take risks with them. If someone is knowledgable on this and can give me reliable instructions or point me to a resource where I might find them, I would still consider essential oils. Someone suggested hydrosols as an alternative and they seem to be perfectly safe, but I'm having trouble finding papers testifying to their bactericidal properties, only bafcteristatic (meaning, they inhibit). These are still an option as well, I need some evidence they can kill germs. So then I got onto honey, because it can both kill germs AND has anti-inflammatory properties. But honey has some problems which I won't get into, because this post is too long already. An alternative candidate I'm looking at now (tho honey is still in play) is olive oil, which, likewise, has both anti-microbial and anti-inflammatory properties and is, obviously, a food, so should be safe for topical application. If anyone knows anything on olive oil and can advise me on this, I'd appreciate it, because I wasted whole of yesterday on reading papers about the anti-microbial properties of various honeys and I'd very much like to not repeat that, as I have a life to get back to Beyond that, if you have any suggestions for an anti-bacterial and an anti-inflammatory, I'd love to hear them.

I have a browser extension that makes background black and text bright to make things easier on the eyes, so I didn't even notice my post was in white font. Dunno why that happened. Can you think of any cheap, natural substance with broad antibiotic properties that I might use for this purpose? Something that can safely be applied topically to the scalp? I've been thinking about honey, but I can't tell from the papers I've been reading whether it merely INHIBITS colonization by bacteria or whether it actually KILLS bacteria that is there. When a paper says that honey INHIBITS bacteria, are they making a distinction there between inhibiting and killing or can I take "inhibits" to mean it kills bacteria? I can't edit the original post, so here's a repost in non-magical ink: Are there any essential oils that are known to be perfectly safe for topical (or oral) application by humans? I am looking for a topical anti-microbial to use in a hair loss regimen. Tea tree oil has been used effectively in a study I read, but I'm concerned about toxicity, so I'm looking for an alternative. I'm looking for something that could safely be applied to the scalp. Does anyone have any suggestions as to what I might look into as a possibility?

Are there any essential oils that are known to be perfectly safe for topical (or oral) application by humans? I am looking for a topical anti-microbial to use in a hair loss regimen. Tea tree oil has been used effectively in a study I read, but I'm concerned about toxicity, so I'm looking for an alternative. I'm looking for something that could safely be applied to the scalp. Does anyone have any suggestions as to what I might look into as a possibility?

I recently heard a girl talk about how she says she likes sweet, nice guys, but when she actually meets one, she finds that she finds them boring and that she is attracted to guys who treat her like trash. Is there some evo psych explanation to this and why girls like bad boys more generally and why nice guys are boring?

What are some examples of scientists who behaved in ways that were unusual or autistic or eccentric. I'm especially interested in obsessive behavior, but anything unusual.

I'm filling out a form and I'm required to give the following information Mailing Address – In Care Of Address Line 1 Address Line 2 City/Town District/Country/Province/ State Postal Code/Zip Code Country Now, I have two questions: 1) What does "in care of" mean? Is that supposed to be my name or the name of the owner of the house or the name on the postal box? 2) What goes into address line 1 and what goes in 2? I just have a street name and number and I live in a house, I don't need 2 address lines. NOTE: This is an American form, so I need answers from folks from the US. I think what address line 1 and 2 are might be different in the UK and elsewhere.

I was watching the below video on cleaning contact lenses, which have to be sterile when you put them in your eyes or you risk an eye infection. The video says take your lenses out, put them in this container of hydrogen peroxide and seal them up. You leave them in there for 6 hours and the hydrogen peroxide gets converted to saline and then they say the lenses can stay in there for 7 days. I'm wondering, what if the lenses were to be left there indefinitely? How could they get infected if everything in the container had been killed by the hydrogen peroxide? Is there any chance they could get infected if left in there for a month and if so how, where would the life come from? Again, the container is completely sealed.

I'm listening to a podcast and a guy on the podcast says "positivism has been refuted, in so far as any philosophy can be refuted, and it's the analytic philosophers who did it." I'm pretty ignorant on history of philosophy, can someone explain what he is talking about? What is the refutation of positivism and came up with it?

The guy on the podcast said that there is always an alpha in bonobo societies and that sometimes it's a female and sometimes it's a male, but that, interestingly, any who is an alpha has a living mother and when his mother dies he can no longer be an alpha. (I wonder what that dynamic is about) But regardless, whether it's a female or a male, does anyone know how the alpha is determined? How is the status established?

I was listening recently to a podcast about bonobos and chimps and how bonobos are much more peaceful and it got me wondering: 1) if there is no violence, how is the status of an alpha male established The guy didn't say that there was absolutely no violence, that's my assumption, so perhaps I'm wrong there and I'm sure that status can be established through games and not direct violence in other species as well, so is it something like that? Does anyone know specifically? 2) How is the status of an alpha male reflected? What exactly distinguishes the alpha male among bonobos from betas?

In my country you choose study programs in high school, you have computer science programs, economics/business programs, programs for hair dressers etc. I went through an economics/business program and I don't know how to list it in my CV. What do I call my degree/title in English? If I were to translate the title given in my country, it would be "economics technician". What do you guys think of that? It sounds kind of goofy to me. Any ideas?

I know nothing about music, so I don't understand stereotypes around genres of music. Someone described someone to me recently as seeming like the kind of guy who listens to indie rock. What does that mean? What does a guy who listens to indie rock look like and what IS he like?

I'm looking at a job advertisement from the Indian embassy and the pay is listed like this: Salary (Per month): - Pay Scale (In Euro) - 1225-50-1975-65-2625-3375 - Basic Salary at the Minimum of Scale: Euro 1225 Does anyone have any idea what the heck "1225-50-1975-65-2625-3375" means??? Also, do you suppose this is gross or net? EDIT: Found another ad of theirs and apparently this is something to do with annual increments and max pay.

I was reading an article and this bit was in there: I don't think I've ever read such a think piece and I'm not familiar with what exactly these arguments are. Could someone link to such an article, if you happen to remember one, or give me a bit more details on what the criticisms are?

Well, I would have thought it's obvious what I mean by folk ethics. It's the ethical judgments that most regular folks will make when using only their innate moral sense, rather than some philosophical and rationally defined moral principle like utilitarianism. In brief - what regular folk think is moral. Don't you agree that that outcome is superior to the utilitarian outcome of killing people to harvest their organs? No, not on one specific thought experiment. We had the trolley problem and the issue of harvesting people's organs. One is a contrived thought experiment, the other is a situation that would happen every day. You could spin out all sorts of scenarios that logically follow from utilitarianism that I'm sure we'd all acknowledge as problems (for example, one creditor with 10 debtors struggling to pay off the loan, so you just tell the creditor to go fly a kite - net happiness has increased), but we don't even need to go there. The organ harvesting one is sufficient. You'd just have people getting put down so others can have their organs left and right. That's a bigger problem, as it would be an everyday occurance, whereas the trolley problem is a contrived philosophical thought experiment that never actually happens.

It could be guys who have the very kind of mental problems that they confer a larger risk of in the offspring, or at least guys who have tendencies in the direction of those problems. So guys who are to a milder or more severer degree autistic, schizophrenic or socially inept in other ways that have connection to mental problems.

I don't think that holds up at all, because, again, the logic of utilitarianism licences you to kill an innocent person to harvest their organs and save multiple people. A non-theoretical, intuitive folk morality prohibits that and is, therefore, better than utilitarianism. And also, this shows you that no utilitarian really acts or thinks as an utilitarian. I don't know what to tell ya on the trolley problem. I don't know what I'd do and I don't know what I'd endorse. I maintain that folk morality is better than utilitarian morality, but I admit that folk morality fails to give an answer here. But, rather than discuss alternatives, I'd prefer to confine the discussion to how utilitarians work out these problems, because if we open up another subject that often derails a thread and I'm very interested, given the popularity of utilitarianism, in how people resolve these issues.

Can anyone recommend any online mags that cover exclusively or primarily math and physics? Something like Quanta. Not exclusively math and physics, but heavy emphasis.