tkadm30

Let's put the facts straight. Cannabinoids really promotes brain cells growth: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ Cannabinoids protects astrocytes from ceramide-induced apoptosis: https://www.ncbi.nlm.nih.gov/pubmed/12133838 Chronic (long-term) THC exposure increases serum BDNF levels in the frontal cortex: https://www.ncbi.nlm.nih.gov/pubmed/22821081 Ultra low dose of THC protects brain cells from inflammation-induced cognitive damage: https://www.ncbi.nlm.nih.gov/pubmed/25042014 In conclusion, the disinformation on cannabis prohibition is all about fear mongering and is not based on scientific data. It is a much safer lifestyle than alcohol drinking or smoking tobacco, if you ask me.

Marijuana smoking is a lifestyle. I seriously doubt that it can "permanently" affect the brain, except in positive ways. Thoses who claims the opposite are either trolls or disinformed, thanks to the government-sponsored propaganda about cannabis prohibition.

You have absolutely no idea how a psychiatric diagnosis is declared. Feel lucky I don't report this as an abusive rant to make people thinking that I'm mentally unstable.

A medical diagnosis and a psychiatric diagnosis are two different things. Psychiatry, unlike medicine, is not evidence-based science. Take it or quit telling me that observations are pure scientific evidences.. https://www.cchrint.org/psychiatric-disorders/psychiatristsphysicians-on-lack-of-any-medicalscientific-tests/ https://en.wikipedia.org/wiki/Scientific_evidence

Since the binding problem of consciousness has not yet been elucidated, I think we're far from seeing mindful machines. Machine intelligence is a software program, and cannot pass the Turing test until we know how/why humans are self-aware.

AI is intrinsically limited by the intelligence of its programmers, so I guess its not possible for machines to "modelize" the unknown using algorithms based on mathematics and physicalism. However, AI can certainly extrapolate models (I prefer the term "theories") of the universe but could probably not produces hard scientific evidences about its validity.

A "mental illness" is not based on scientific evidences, but on the testimonial of the patient to the psychiatrist. Try to find a psychiatrist who will do brain scans to figure out the cause of the mental disorder.

Not all atypical antipsychotics are classical dopamine antagonists (blockers). For example, aripiprazole acts like a dopamine D2R antagonist under high extracellular concentration of dopamine. Under low dopaminergic tone, aripiprazole is a selective D2R ligand (agonist): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360222/ I'm curious about how theses ex vivo alterations of dopaminergic tone may affect differential sensitivity to dopamine agonists. Could a dopamine system stabilizer like aripiprazole trigger neuroleptic malignant syndrome (NMS) ?

Please provide references to support theses claims.

The genetic THC tolerance and CB1 receptor-mediated regulation of Akt/BDNF signaling trigger striatal neuroprotection: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563779/

I doubt seriously atypical antipsychotics are comparable to amphetamines. Apart from that, I guess partial (inverse) dopamine agonists doesn't block dopamine receptors like dopamine antagonists.

Can inverse (partial) agonism at dopamine D2 receptors trigger dopaminergic hypersensitivity?

Atypical antipsychotics (inverse dopamine agonists) are thought to cause fewer extrapyramidal symptoms than typical antipsychotics.

Can atypical antipsychotics inverse dopamine sensitivity?

How can long-term neuroleptic drug (not cannabis) usage trigger psychosis? Is it possible that atypical antipsychotics inverse chemical balance (dopamine/serotonin levels) in the brain? Can atypical antipsychotics cause dopamine hypersensitivity? Thanks.

I'm looking for papers describing theories of quantum-like neuronal communication models. In particular, I'm interested in the biological entanglement of physical (neuronal) processes and the neurophenomenology of consciousness. Thank you,

"Enlighten the people generally, and tyranny and oppressions of body and mind will vanish like evil spirits at the dawn of day." -Thomas Jefferson

See this: https://en.wikipedia.org/wiki/God_gene

Yes. Exercise stimulate dopamine neurotransmission through calmodulin-dependent pathways in the brain: https://www.ncbi.nlm.nih.gov/pubmed/12758062

OK. Thanks for this information, jbn22.

Increasing the amount of GABA reduces seizure activity and/or anxiety. https://www.ncbi.nlm.nih.gov/pubmed/11520315

Here's some cool papers on the science of mind wandering and the neurophenomenology of consciousness. http://www.ini.ch/~alumit/ishai_jocn2002.pdf https://www.ncbi.nlm.nih.gov/pubmed/25293689 http://www.mitpressjournals.org/doi/abs/10.1162/jocn_a_00656

Yes. There is one conscious level but multiple streams of consciousness. Unconsciousness is defined by the absence of multiple streams of conscious activity.

Thanks for the information. It looks like the mind can switch between streams of consciousness. I have noticed smoking tobacco produces this psychological effect.