Serotonin syndrome

[DevilSolution]

Can you get serotonin syndrome with the use of a highly selective serotonin agonist alone? without the use of SSRI's.

 

And when do you know you have serotonin syndrome? from personal experience mostly all highly selective serotonin agonists, of say the the 5-ht2b receptor give you the same symptoms as that are described as serotonin syndrome i.e (increased heart rate, sweating, dilated pupils, comeup shits etc) are all generic symptoms of highly selective agonists without the use of SSRI's. So wheres the threshold to know when your in danger?

 

And can dopamine RI's or RA's effect this syndrome or is it only relative to serotonin agents.

[John Cuthber]

Can you get serotonin syndrome with the use of a highly selective serotonin agonist alone? without the use of SSRI's.

 

 

Yes

"Many cases of serotonin toxicity occur in patients who have ingested drug combinations that synergistically increase synaptic serotonin.^[5] It may also occur as a symptom of overdose of a single serotonergic agent.^[20] "

https://en.wikipedia.org/wiki/Serotonin_syndrome

[DevilSolution]

So when do you know you've hit the threshold? as i mentioned through personal experience the symptoms are almost generic for all highly selective serotonin agonists.

 

for example MDAI is a non neurotoxic highly selective agonist of the 2b receptor, according to wiki it has had 3 deaths associated with it via suspected serotonin syndrome, does that mean they reacted badly or took to much?

 

https://en.wikipedia.org/wiki/MDAI

Edited November 29, 2015 by DevilSolution

[John Cuthber]

I'm not sure if this topic is suitable for this sort of discussion. I'm not sure if I should suggest that you talk to your doctor or to your lawyer.

[DevilSolution]

Lawyer? hmmmm.....

 

Im just curious, as i said ive had previous experience of selective agonists and wanted to know when common symptoms become threshold given that the symptoms are fairly generic of that class of drugs.

[Xalatan]

Good question - if you combined monoamine oxidase inhibitor with a specific serotonin agonist that was selectively vasoactive you could probably still induce ss. The threshold would need to look at vitals and the clinical picture - there are probably clinical criteria that define serotonin syndrome but if someone is decompromised from serotonin overdose then this may be ss.