Gen1GT Posted September 17, 2014 Share Posted September 17, 2014 Hi everyone. I was reading some research, and noticed Omentin-1, but upon consulting the internet, I only arrived at more research papers, but no explanation of what it is. Does anyone know what Omentin-1 is? Thanks, Link to comment Share on other sites More sharing options...
Dislayer Posted September 17, 2014 Share Posted September 17, 2014 Omentin-1 appears to be an Adipokine (adipose cytokine) that can also be called inelectin-1 (ITLN1). It seems to be a very popular molecule right now in obesity/diabetes research (couple hundred hits on Pubmed [omentin-1 + diabetes]). Some research seems to suggest that its levels are down in the blood of obese patients or patients with diabetes Changes of serum omentin-1 levels in normal subjects, type 2 diabetes and type 2 diabetes with overweight and obesity in Chinese adults. CONCLUSION:Decreased omentin-1 levels may contribute to the development of insulin resistance, T2DM and particularly to obesity in Chinese adults, however, its role in these diseases needs to be fully elucidated. Low omentin-1 levels are related with clinical and metabolic parameters in obese children.Our data indicates that serum omentin 1 levels are i) lower in obese children and ii) negatively correlated with BMI, WC, HOMA-IR and insulin levels suggesting that omentin 1 might be a biomarker for metabolic dysfunction also in childhood and adolescence. It also seems to have a cardioprotective effect and may be beneficial in type 2 diabetes Cardioprotective Properties of Omentin-1 in Type 2 Diabetes: Evidence from Clinical and In Vitro Studies These data identify omentin-1 as a cardioprotective adipokine, and indicate that decreases in omentin-1 levels could contribute to the induction of cardiovascular dysfunction in DM2 (Type II diabetes). This review give a good overview of the anti-inflammatory effects of omentin-1 and other adipokines (Role of anti-inflammatory adipokines in obesity-related diseases). Briefly, they indicate that omentin-1 is abundantly expressed in the visceral fat and is detectable circulating in the blood. Some work has shown that omentin-1 stimulates glucose uptake in cultured adipose cells. It may also enhance dilation of the blood vessels through the production of endothelial NO. Omentins anti-inflammatory effects seem to be through the suppression of immune cell adhesion to the endothelial walls. Seems like this protein holds some promise in finding a way to treat diabetes and obesity. Don't know if this answered your question. The literature out there is still fairly new. Link to comment Share on other sites More sharing options...
CharonY Posted September 17, 2014 Share Posted September 17, 2014 (edited) Well, there is a lot of information on it, is there anything particular you are interested in? Essentially it is a protein that belongs to the family of cytokines that are typically involved in cell signaling. Omentin-1 is, to my knowledge, secreted by adipose (fat) tissue. edit: crossposted. Edited September 17, 2014 by CharonY Link to comment Share on other sites More sharing options...
Gen1GT Posted September 17, 2014 Author Share Posted September 17, 2014 Well, I am trying to find some research on Leptin and how it correlates with weight-loss/weight-gain. Specifically, and I doubt this research exists, I am curious how much leptin drops during caloric deficit, and how much leptin increases during caloric surplus in those same patients. Some of the studies showed relationships between leptin and omentin-1, but I don't know what omentin-1 is. Dislayers, thanks for the references. It appears from your links that it's a signalling protein. Link to comment Share on other sites More sharing options...
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