Efflux pumps and MDR

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Efflux pumps and MDR Efflux pumps Rate Topic:

#1 15 January 2012 - 07:58 AM linenup

Lepton

Hi: Thank you for answering my question. My question is concerning the efflux pump and MDR

1/ I was under the belief that efflux pumps were specific to biofilm formation, if the pathogen is not a biofilm related organism, can efflux pumps still exist?

2/ Are efflux pumps the main obstacle in multi drug resistance?

3/ Does anyone have any resources on natural or pharma efflux pump disablers?

Thanks for your insight!

Posts: 2 | Joined: 15-January 12
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#2 16 January 2012 - 04:10 PM CharonY

Biology Expert

Based on your question I assume that you mean bacterial efflux pumps.

1) No, they are not specific to biofilms. I assume that you learned about them in this particular context, but there are a large variety of efflux pumps. Most are involved in detoxification, though.

2) Not necessarily, there are other mechanisms. However, they are a very common theme.

3) It is not really my field, but there is quite a body of literature regarding inhibitors out there. For instance: J. Antimicrob. Chemother. (2007)59 (6): 1247-1260.