tkadm30 Posted January 28, 2017 Share Posted January 28, 2017 (edited) It appears the role of the AKT1 genotype has been implicated in THC tolerance. Interestingly, delta9-tetrahydrocannabinol (THC) may activate the AKT1 gene in vitro and in vivo. This pharmacological activation of the AKT1 gene by THC might explain why THC administration is neuroprotective in Alzheimer's disease. Edited January 28, 2017 by tkadm30 Link to comment Share on other sites More sharing options...
StringJunky Posted January 28, 2017 Share Posted January 28, 2017 (edited) It appears the role of the AKT1 genotype has been implicated in THC tolerance. Interestingly, delta9-tetrahydrocannabinol (THC) may activate the AKT1 gene in vitro and in vivo. This pharmacological activation of the AKT1 gene by THC might explain why THC administration is neuroprotective in Alzheimer's disease. Your question is? Edited January 28, 2017 by StringJunky Link to comment Share on other sites More sharing options...
tkadm30 Posted January 28, 2017 Author Share Posted January 28, 2017 Your question is? If antipsychotics enhances AKT1 signaling, does it increases THC tolerance ? Link to comment Share on other sites More sharing options...
tkadm30 Posted February 17, 2017 Author Share Posted February 17, 2017 The genetic THC tolerance and CB1 receptor-mediated regulation of Akt/BDNF signaling trigger striatal neuroprotection: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563779/ Link to comment Share on other sites More sharing options...
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